髋关节镜检查患者术前使用阿片类药物与术前患者报告结局较差相关。

Preoperative opioid use is associated with worse preoperative patient-reported outcomes in hip arthroscopy patients.

机构信息

Department of Orthopaedics, University of Maryland School of Medicine, 2200 Kernan Drive, Baltimore, MD, 21207, USA.

出版信息

J ISAKOS. 2024 Aug;9(4):581-586. doi: 10.1016/j.jisako.2024.04.016. Epub 2024 Apr 30.

Abstract

OBJECTIVES

The purpose of this study was to define the rate of preoperative opioid use among patients undergoing hip arthroscopy, ascertain which clinical factors are associated with opioid use, and assess the effect of preoperative opioid usage on preoperative patient-reported outcome (PRO) measures.

METHODS

A single institution orthopedic registry was retrospectively analyzed for patients undergoing hip arthroscopy for femoroacetabular impingement (FAI) syndrome with or without labral tear between 2015 and 2022. Patients completed Patient-Reported Outcomes Measurement Information System (PROMIS) in six domains, Numeric Pain Scores (NPS), and Musculoskeletal Outcomes Data Evaluation and Management System expectations domain preoperatively. Patients' charts were reviewed to determine demographic factors and identify any active opioid prescription within 6 weeks before surgery. Bivariate analysis was used to determine associations between preoperative opioid use and baseline PROs. Statistically significant bivariate associations were further tested by multivariate analysis to determine independent predictors.

RESULTS

A total of 123 patients were included (age 39.7 ​± ​12.0 years; 87 females; body mass index 27.4 ​± ​5.7 kg/m). There were 21 patients (17%) using opioids preoperatively. Prior orthopedic or other surgery and lower education level were associated with preoperative opioid use. Patients with preoperative opioid use scored statistically significantly worse compared with those without preoperative opioid use on baseline PROMIS Physical Function (38.6 vs 40.5, p ​= ​0.01), Pain Interference (65.9 vs 60.2, p ​= ​0.001), Fatigue (60.7 vs 51.6, p ​= ​0.005), Social Satisfaction (38.2 vs 43.2, p ​= ​0.007), and Depression (54.2 vs 48.8, p ​= ​0.01). Preoperative opioid use was also associated with statistically significantly worse preoperative NPS for both the operative hip (6.3 vs 4.6, p ​= ​0.003) and whole body (3.0 vs 1.4, p ​= ​0.008). Preoperative opioid use was an independent predictor of worse baseline PROMIS Pain Interference, Fatigue, Social Satisfaction, and NPS for the operative hip.

CONCLUSION

Patients using opioids preoperatively had worse baseline PROs for physical function, pain, social satisfaction, and depression than those not using opioids preoperatively. When controlling for confounding variables, preoperative opioid use was independently predictive of worse baseline pain, fatigue, and social satisfaction.

LEVEL OF EVIDENCE

Level III, prognostic study.

摘要

目的

本研究旨在确定行髋关节镜检查患者术前阿片类药物使用的比例,确定与阿片类药物使用相关的临床因素,并评估术前阿片类药物使用对术前患者报告的结局(PRO)测量的影响。

方法

对 2015 年至 2022 年间因股骨髋臼撞击症(FAI)综合征伴或不伴盂唇撕裂而行髋关节镜检查的患者,对单一机构的骨科登记处进行回顾性分析。患者在术前完成了包含六个领域的患者报告的结果测量信息系统(PROMIS)、数字疼痛评分(NPS)和肌肉骨骼结果数据评估和管理系统的期望领域。对患者的病历进行审查,以确定人口统计学因素,并确定手术前 6 周内是否有任何有效的阿片类药物处方。采用双变量分析确定术前阿片类药物使用与基线 PRO 之间的关联。对具有统计学意义的双变量关联进一步进行多变量分析,以确定独立的预测因素。

结果

共纳入 123 例患者(年龄 39.7 ± 12.0 岁;87 例女性;体重指数 27.4 ± 5.7 kg/m2)。有 21 例(17%)患者术前使用阿片类药物。既往骨科或其他手术史和较低的教育水平与术前阿片类药物使用相关。与无术前阿片类药物使用的患者相比,使用术前阿片类药物的患者在基线 PROMIS 躯体功能(38.6 分 vs. 40.5 分,p=0.01)、疼痛干扰(65.9 分 vs. 60.2 分,p=0.001)、疲劳(60.7 分 vs. 51.6 分,p=0.005)、社交满意度(38.2 分 vs. 43.2 分,p=0.007)和抑郁(54.2 分 vs. 48.8 分,p=0.01)方面的评分显著更差。术前阿片类药物使用也与术前 NPS (手术髋关节为 6.3 分 vs. 4.6 分,p=0.003)和全身体重为 3.0 分 vs. 1.4 分,p=0.008)显著更高相关。术前阿片类药物使用是基线 PROMIS 疼痛干扰、疲劳、社交满意度和手术髋关节 NPS 更差的独立预测因素。

结论

与未使用术前阿片类药物的患者相比,使用术前阿片类药物的患者在躯体功能、疼痛、社交满意度和抑郁方面的基线 PRO 更差。在校正混杂变量后,术前阿片类药物的使用与基线疼痛、疲劳和社交满意度更差具有独立相关性。

证据等级

III 级,预后研究。

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