College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China.
J Cosmet Dermatol. 2024 Sep;23(9):2785-2792. doi: 10.1111/jocd.16353. Epub 2024 May 1.
The exact pathogenesis of melasma is not yet known, and its treatment remains challenging. Mesotherapy with tranexamic acid (TXA) and vitamin C was both reported to have certain effects on melasma. In spite of that several articles have compared the efficacy and safety of the two drugs on melasma, most of them were clinical study with small sample size.
To evaluate the efficacy and safety of mesotherapy with TXA versus vitamin C in treating melasma through meta-analysis and systemic review.
The authors searched PubMed, Web of Science, Springer, and ScienceDirect for studies that compared mesotherapy with TXA versus vitamin C as a treatment for melasma. Primary outcomes were change in melasma area and severity index (MASI) before and after the treatment.
Finally, five studies with a total of 127 patients were included in the systematic review. There was no statistic difference in the change in MASI score between the TXA and vitamin C groups (mean difference, 0.16; 95% CI, -0.79 to 1.11).
Mesotherapy with both TXA and vitamin C is safe and effective in the treatment of melasma.
黄褐斑的确切发病机制尚不清楚，其治疗仍然具有挑战性。氨甲环酸（TXA）和维生素 C 的 微针疗法均被报道对黄褐斑有一定疗效。尽管有几篇文章比较了这两种药物治疗黄褐斑的疗效和安全性，但大多数都是样本量较小的临床研究。
通过荟萃分析和系统评价评估 TXA 微针疗法与维生素 C 微针疗法治疗黄褐斑的疗效和安全性。
作者检索了 PubMed、Web of Science、Springer 和 ScienceDirect 中比较 TXA 微针疗法与维生素 C 微针疗法治疗黄褐斑的研究。主要结局指标为治疗前后黄褐斑面积和严重程度指数（MASI）的变化。
最终，系统评价纳入了 5 项共 127 例患者的研究。TXA 和维生素 C 组 MASI 评分的变化无统计学差异（平均差异，0.16；95%CI，-0.79 至 1.11）。
TXA 和维生素 C 的微针疗法治疗黄褐斑均安全有效。
