Dhondge Rushikesh H, Agrawal Sachin, Kumar Sunil, Acharya Sourya, Karwa Vineet
Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Mar 31;16(3):e57365. doi: 10.7759/cureus.57365. eCollection 2024 Mar.
Serum ferritin has garnered considerable attention as a prognostic marker in intensive care units (ICUs), offering valuable insights into patient outcomes and clinical management strategies. This comprehensive review examines the role of serum ferritin in predicting outcomes among critically ill patients, with a particular focus on its implications for ischemic heart disease (IHD). Elevated serum ferritin levels have consistently been associated with adverse outcomes in ICU settings, including increased mortality, prolonged hospital stays, and higher morbidity rates. Furthermore, the relationship between serum ferritin levels and IHD underscores its potential as a biomarker for cardiovascular risk assessment in critically ill populations. The review synthesizes existing literature to highlight the predictive value of serum ferritin in assessing illness severity and guiding clinical decision-making in the ICUs. It also explores potential mechanisms linking serum ferritin to adverse outcomes and discusses implications for clinical practice. Integrating serum ferritin measurements into routine assessments could enhance prognostication and risk stratification in ICU patients, while further research is needed to elucidate optimal management strategies and therapeutic targets. Collaborative efforts between clinicians and researchers are essential to advance our understanding of serum ferritin's prognostic value in the ICUs and translate this knowledge into improved patient care and outcomes.
血清铁蛋白作为重症监护病房（ICU）中的一种预后标志物已受到广泛关注，它为患者预后及临床管理策略提供了有价值的见解。这篇综述全面探讨了血清铁蛋白在预测重症患者预后方面的作用，尤其关注其对缺血性心脏病（IHD）的影响。在ICU环境中，血清铁蛋白水平升高一直与不良预后相关，包括死亡率增加、住院时间延长和发病率升高。此外，血清铁蛋白水平与IHD之间的关系凸显了其作为重症人群心血管风险评估生物标志物的潜力。该综述综合现有文献，以突出血清铁蛋白在评估ICU疾病严重程度和指导临床决策方面的预测价值。它还探讨了将血清铁蛋白与不良预后联系起来的潜在机制，并讨论了对临床实践的影响。将血清铁蛋白检测纳入常规评估可改善ICU患者的预后评估和风险分层，不过仍需进一步研究以阐明最佳管理策略和治疗靶点。临床医生和研究人员之间的合作对于加深我们对血清铁蛋白在ICU中预后价值的理解，并将这一知识转化为改善患者护理和预后至关重要。
