Alsumadi Maen, Basha Asma, AlSumadi Amro, Obeidat Zeina, AbuKhalaf Bashar, Sulieman Abdelrahman, Shuwehdi Sleman, AlDeffaie Abdullah, AlQaqaa Ahmed, Zakaryia Aiman
Obstetrics and Gynaecology, Epsom and St Helier University Hospitals, London, GBR.
Obstetrics and Gynaecology, The University of Jordan, Amman, JOR.
Cureus. 2024 Mar 31;16(3):e57360. doi: 10.7759/cureus.57360. eCollection 2024 Mar.
Tranexamic acid (TXA) use in obstetric hemorrhage has been shown to decrease both maternal mortality and morbidity. This study aimed to explore the knowledge and attitudes of Jordanian obstetricians and gynecologists regarding the use of TXA in obstetric bleeding cases, as well as to identify factors that affect decision-making processes and emphasize the significance of TXA in enhancing maternal health outcomes.
This study used a cross-sectional design and a structured questionnaire to gather data from a convenience sample of 1000 Jordanian obstetricians.
Most participants used TXA to address obstetric hemorrhage, with medical training being the primary source of knowledge about TXA for (113/166) 68.1% of respondents. Awareness of TXA's potential benefits was high but some misconceptions existed. Approximately (96/166) 57.8% of the participants were aware of the recommended dosage regimen, and (61/166) 36.7% emphasized the importance of timing of administration. Knowledge of potential side effects was notable, with (55/166) 33.1% aware of life-threatening side effects, such as pulmonary embolism and deep vein thrombosis. Concerns regarding barriers to implementation included the absence of strict guidelines (54.8%) and drug availability ( 91/166; 54.8%). However, (64/166) 38.6% expressed confidence in the effective use of TXA for obstetric hemorrhage treatment. The majority of respondents (154/166; 92.8%) considered additional education and training on TXA use to be important in managing obstetric hemorrhage.
Jordanian obstetricians have used TXA in cases of obstetric hemorrhage despite their experience and knowledge based only on limited resources; the need for national guidelines on when and how to use TXA in obstetric practice is of great importance and got vast support from the Jordanian obstetricians.
已证明氨甲环酸（TXA）用于产科出血可降低孕产妇死亡率和发病率。本研究旨在探讨约旦妇产科医生对TXA在产科出血病例中使用的知识和态度，确定影响决策过程的因素，并强调TXA在改善孕产妇健康结局方面的重要性。
本研究采用横断面设计，并使用结构化问卷从1000名约旦妇产科医生的便利样本中收集数据。
大多数参与者使用TXA来处理产科出血，医学培训是（113/166）68.1%的受访者了解TXA的主要知识来源。对TXA潜在益处的知晓率较高，但也存在一些误解。约（96/166）57.8%的参与者知晓推荐的给药方案，（61/166）36.7%的参与者强调给药时机的重要性。对潜在副作用的了解较为显著，（55/166）33.1%的人知晓危及生命的副作用，如肺栓塞和深静脉血栓形成。对实施障碍的担忧包括缺乏严格的指南（54.8%）和药物可及性（91/166；54.8%）。然而，（64/166）38.6%的人对TXA有效治疗产科出血表示有信心。大多数受访者（154/166；92.8%）认为关于TXA使用的额外教育和培训对管理产科出血很重要。
约旦妇产科医生在产科出血病例中使用了TXA，尽管他们仅基于有限资源的经验和知识；制定关于何时以及如何在产科实践中使用TXA的国家指南非常重要，并得到了约旦妇产科医生的广泛支持。
