Department of Pharmacy, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria.
Int J Gynaecol Obstet. 2024 Feb;164(2):668-676. doi: 10.1002/ijgo.15176. Epub 2023 Oct 10.
This study was conducted to determine the knowledge, practice, and barriers regarding the use of tranexamic acid (TXA) for the prevention and treatment of postpartum hemorrhage (PPH) among health care providers in Enugu, Nigeria.
A cross-sectional study was conducted among health professionals (doctors, pharmacists, and nurses) in two Nigerian tertiary teaching hospitals (one federal and one state). A total of 220 questionnaires were distributed and 207 were returned (response rate: 94%) and analyzed using SPSS for inferential statistics with a level of significance of P < 0.05.
Only 23.7% of the respondents had good knowledge of TXA use in PPH (P < 0.001), and awareness of the recent World Health Organization (WHO) recommendation on the use of TXA for PPH was low (19.8%, P < 0.001). The majority of the respondents had neither prescribed nor dispensed TXA (30%, P < 0.001). Very few respondents used TXA for all cases of PPH (16.4%, P < 0.001). Barriers against its use include nonawareness of the latest WHO recommendation, preference for other uterotonics, and cost of the drug.
There was poor knowledge of TXA, poor awareness of its recommendation, and low use for PPH among different cadres of health care providers.
本研究旨在确定尼日利亚埃努古的医疗保健提供者在使用氨甲环酸（TXA）预防和治疗产后出血（PPH）方面的知识、实践和障碍。
在尼日利亚的两家三级教学医院（一家联邦和一家州立医院）中对医疗专业人员（医生、药剂师和护士）进行了横断面研究。共发放了 220 份问卷，有 207 份（回应率：94%）被返回并使用 SPSS 进行了推断统计分析，显著性水平为 P < 0.05。
只有 23.7%的受访者对 TXA 在 PPH 中的使用有良好的认识（P < 0.001），并且对最近世界卫生组织（WHO）关于 TXA 在 PPH 中使用的建议认识较低（19.8%，P < 0.001）。大多数受访者既没有开也没有配 TXA（30%，P < 0.001）。只有极少数的受访者在所有 PPH 病例中都使用 TXA（16.4%，P < 0.001）。反对使用 TXA 的障碍包括不了解最新的 WHO 建议、偏爱其他子宫收缩剂和药物的费用。
不同级别的医疗保健提供者对 TXA 的认识较差，对其建议的认识较差，并且在 PPH 中的使用率较低。
