Sahyouni Mark, Casey Bradley, Carpenter Zachary, Estrella Frank, Okafor Chika
Internal Medicine, Campbell University School of Osteopathic Medicine, Buies Creek, USA.
Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Cureus. 2024 Apr 1;16(4):e57419. doi: 10.7759/cureus.57419. eCollection 2024 Apr.
Creutzfeldt-Jakob disease (CJD) constitutes an aggressively advancing, terminal neurodegenerative condition classified within the spectrum of transmissible spongiform encephalopathies. The difficulty in establishing a diagnosis before death arises from the condition's rarity and the resulting limited level of suspicion attributed to it. The polymorphic nature of CJD symptoms contributes to the challenge of early diagnostic recognition. Emotional and behavioral changes have been well documented, but the initial presentation of euphoria has not been documented. Here, we present the case of a female patient who was experiencing an unusual state of euphoria followed by intermittently altered mental status. She was ultimately diagnosed with sporadic CJD, discharged home on hospice, and died within six months of discharge.
克雅氏病（CJD）是一种进展迅速的终末期神经退行性疾病，属于可传播性海绵状脑病范畴。生前难以确诊该病，原因在于其罕见性以及由此导致的可疑程度有限。克雅氏病症状的多态性增加了早期诊断识别的难度。情绪和行为变化已有充分记录，但欣快感作为初始表现尚未见报道。在此，我们报告一例女性患者，该患者先出现异常的欣快状态，随后精神状态间歇性改变。她最终被诊断为散发性克雅氏病，出院后接受临终关怀，出院后六个月内死亡。
