Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pediatr Pulmonol. 2024 Oct;59(10):2464-2471. doi: 10.1002/ppul.27039. Epub 2024 May 2.
Lung T1 MRI is a potential method to assess cystic fibrosis (CF) lung disease that is safe, quick, and widely available, but there are no data in children with mild CF lung disease.
Assess the ability of lung T1 MRI to detect abnormalities in children with mild CF lung disease.
We performed T1 MRI, multiple breath washout (MBW), chest computed tomography (CT), and spirometry in a cohort of 45 children with mild CF lung disease (6-11 years of age).
Despite mean normal ppFEV1 values, the majority of children with CF in this study exhibited mild lung disease evident in lung clearance index (LCI) measured by MBW, chest CT Brody scores, and percent normal lung perfusion (%NLP) measured by T1 MRI. The %NLP correlated with chest CT Brody scores, as did LCI, but %NLP and LCI did not correlate with each other. Analysis of the Brody subscores showed that %NLP and LCI largely correlated with different Brody subscores.
T1 MRI can detect mild CF lung disease in children and correlates with chest CT findings. The %NLP from T1 MRI and LCI correlate with different chest CT Brody subscores, suggesting they provide complementary information about CF lung disease.
肺部 T1 磁共振成像（MRI）是一种评估囊性纤维化（CF）肺部疾病的潜在方法，具有安全、快速和广泛应用的特点，但在轻度 CF 肺部疾病的儿童中尚无相关数据。
评估肺部 T1 MRI 在轻度 CF 肺部疾病儿童中的检测异常能力。
我们对 45 名患有轻度 CF 肺部疾病的儿童（6-11 岁）进行了 T1 MRI、多次呼吸冲洗（MBW）、胸部计算机断层扫描（CT）和肺功能检查。
尽管平均 ppFEV1 值正常，但本研究中大多数 CF 患儿表现出轻度肺部疾病，这在 MBW 测量的肺清除指数（LCI）、胸部 CT Brody 评分和 T1 MRI 测量的 %正常肺灌注（%NLP）中都有所体现。%NLP 与胸部 CT Brody 评分相关，LCI 也是如此，但 %NLP 和 LCI 彼此之间并不相关。Brody 子评分分析表明，%NLP 和 LCI 与不同的 Brody 子评分高度相关。
T1 MRI 可检测儿童的轻度 CF 肺部疾病，与胸部 CT 发现相关。T1 MRI 的 %NLP 和 LCI 与不同的胸部 CT Brody 子评分相关，提示它们提供了关于 CF 肺部疾病的补充信息。
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