Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
University of Zurich, Zurich, Switzerland.
Eur Radiol. 2018 Oct;28(10):4037-4047. doi: 10.1007/s00330-018-5383-5. Epub 2018 Apr 13.
To demonstrate, in patients with cystic fibrosis (CF), the correlation between three-dimensional dynamic oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements and computed tomography Brody score (CF-CT) and lung function testing (LFT).
Twenty-one patients (median age, 25 years; female, n = 8) with a range of CF lung disease and five healthy volunteers (median age, 31 years; female, n = 2) underwent OE-MRI performed on a 1.5-T MRI scanner. Coronal volumes were acquired while patients alternately breathed room air and 100% oxygen. Pre-oxygen T was measured. Dynamic series of T-weighted volumes were then obtained while breathing oxygen. T-parameter maps were generated and the following OE-MRI parameters were measured: oxygen uptake (ΔPO), wash-in time and wash-out time. High-resolution CT and LFT were performed. The relationship between CF-CT, LFT and OE-MRI parameters were evaluated using Pearson correlation for the whole lung and regionally.
Mean CF-CT was 24.1±17.1. Mean ΔPO and mean wash-in as well as skewness of wash-out showed significant correlation with CF-CT (ΔPO: r = -0.741, p < 0.001; mean wash-in: r = 0.501, p = 0.017; skewness of wash-out: r = 0.597, p = 0.001). There was significant correlation for the whole lung and regionally between LFT parameters and OE-MR (ΔPO: r = 0.718, p < 0.001; wash-in: r = -0.576, p = 0.003; wash-out skewness: r = -0.552, p = 0.004).
Functional lung imaging using OE-MRI has the capability to assess the severity of CF lung disease and shows a significant correlation with LFT and CF-CT.
• Oxygen-enhanced MRI might play a future role in evaluation and follow-up of cystic fibrosis. • Heterogeneity of parameter maps reflects localised functional impairment in cystic fibrosis. • Avoidance of cumulative radiation burden in CF is feasible using OE-MRI.
在囊性纤维化（CF）患者中，证明三维动态氧增强磁共振成像（OE-MRI）测量值与 CT 布罗迪评分（CF-CT）和肺功能测试（LFT）之间的相关性。
21 名 CF 肺部疾病患者（中位年龄 25 岁；女性 8 名）和 5 名健康志愿者（中位年龄 31 岁；女性 2 名）在 1.5-T MRI 扫描仪上进行 OE-MRI。患者在交替呼吸室内空气和 100%氧气时采集冠状位容积。测量预氧 T 值。然后在吸氧时获得动态 T 加权容积系列。生成 T 参数图，并测量以下 OE-MRI 参数：氧摄取（ΔPO）、灌注时间和洗脱时间。进行高分辨率 CT 和 LFT。使用 Pearson 相关性评估整个肺和区域的 CF-CT、LFT 和 OE-MRI 参数之间的关系。
平均 CF-CT 为 24.1±17.1。平均 ΔPO 和平均灌注以及洗脱的偏度与 CF-CT 呈显著相关（ΔPO：r=-0.741，p<0.001；平均灌注：r=0.501，p=0.017；洗脱偏度：r=0.597，p=0.001）。整个肺和区域 LFT 参数与 OE-MR 之间存在显著相关性（ΔPO：r=0.718，p<0.001；灌注：r=-0.576，p=0.003；洗脱偏度：r=-0.552，p=0.004）。
使用 OE-MRI 进行功能性肺部成像能够评估 CF 肺部疾病的严重程度，并与 LFT 和 CF-CT 有显著相关性。
• 氧增强 MRI 可能在 CF 的评估和随访中发挥作用。
• 参数图的异质性反映了 CF 中的局部功能障碍。
• 使用 OE-MRI 可以避免 CF 中累积的辐射负担。
