Brun B
Arch Anat Histol Embryol. 1978;61:63-88.
Uterine terminal vessels are ligatured in the rabbit. These reduction of the utero-placental blood supply during the pregnancy is one "intra-uterine growth retardation" factor. These I.U.G.R. rabbits shown one important decrease of their total cellular population. More the intervention is executed near the term more the cerebral mass is affected. At the beginning of the pregnancy one teratogenic effect is superadded to the I.U.G.R. effect. Modification of the blood supply before pregnancy with the same proceeding product on decrease of the implantation, one I.U.G.R. effect and one teratogenic effect.
在兔子身上结扎子宫末梢血管。孕期子宫胎盘血液供应的这种减少是“宫内生长受限”的一个因素。这些宫内生长受限的兔子显示其总细胞数量显著减少。干预实施得越接近足月,脑质量受影响就越大。在怀孕初期,致畸作用叠加在宫内生长受限的影响之上。在怀孕前用相同的操作方法改变血液供应会导致着床减少、出现宫内生长受限效应和致畸效应。