Griffe O, Griffe H, du Cailar J
Ann Anesthesiol Fr. 1979;20(1):37-40.
Oxygen consumption (VO2) was measured in ten patients before and after the administration of 0.28 mg.kg-1 of diazepam, using a spirometer placed in the circuit of an MA1 respirator functioning on a closed circuit basis. The results showed a significant decrease in VO2 OF 8 p. 100. The differences seen in comparison with previous studies may be explained by differences in the methods of study used. It would appear that this hypometabolic effect is not an intrinsic property of diazepam but rather a consequence of the neurodepressive properties of the drug, on the gamma system in particular.
使用置于基于闭路系统运行的MA1型呼吸机回路中的肺活量计，在10名患者服用0.28mg.kg-1地西泮前后测量了耗氧量（VO2）。结果显示VO2显著降低了8%。与先前研究相比出现的差异可能是由于所采用的研究方法不同所致。看来这种低代谢效应并非地西泮的固有特性，而是该药物神经抑制特性的结果，尤其是对γ系统的抑制。
