MUC4 及其相关蛋白在胰腺和壶腹周围癌中的临床意义。
Clinical Significance of MUC4 and Associated Proteins in Pancreatic and Periampullary Cancers.
机构信息
From the Department of Gastroenterology and HNU.
Department of Pathology.
出版信息
Pancreas. 2024 Aug 1;53(7):e595-e602. doi: 10.1097/MPA.0000000000002340. Epub 2024 May 1.
OBJECTIVE
This study primarily aimed to assess the expression of MUC4 in patients with pancreatic ductal adenocarcinoma (PDAC) as compared with controls and assess its clinical relevance.
MATERIALS AND METHODS
Serum MUC4 levels and MUC4 gene expression in snap-frozen tissue were analyzed through surface plasmon resonance and quantitative polymerase chain reaction, respectively. Tumor tissues and control tissues were analyzed for MUC4 and other mucins through immunohistochemistry.
RESULT
MUC4 expression in tumor tissue was found to be significantly elevated in PDAC patients as compared with chronic pancreatitis tissues and normal pancreatic tissues. Periampullary carcinoma and cholangiocarcinoma tissue also showed increased expression of MUC4 and other mucins.
CONCLUSIONS
Differential expression of MUC4 in pancreatic tumor tissues can help to differentiate PDAC from benign conditions.
目的
本研究主要旨在评估黏蛋白 4（MUC4）在胰腺导管腺癌（PDAC）患者中的表达情况，并与对照组进行比较，同时评估其临床相关性。
材料与方法
通过表面等离子体共振和实时定量聚合酶链反应分别分析血清 MUC4 水平和组织中 MUC4 基因的表达情况。通过免疫组织化学分析肿瘤组织和对照组织中的 MUC4 和其他黏蛋白。
结果
与慢性胰腺炎组织和正常胰腺组织相比，PDAC 患者的肿瘤组织中 MUC4 的表达明显升高。壶腹周围癌和胆管细胞癌组织也显示 MUC4 和其他黏蛋白的表达增加。
结论
胰腺肿瘤组织中 MUC4 的差异表达有助于将 PDAC 与良性病变区分开来。
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