Vincent J W, Suzuki J B, Falkler W A, Cornett W C
J Periodontol. 1985 Aug;56(8):464-9. doi: 10.1902/jop.1985.56.8.464.
The levels of serum antibody reactive to selected periodontopathogens were determined in 182 clinically characterized patients: 35 healthy control, 50 juvenile periodontitis, 42 adult periodontitis and 55 rapidly progressive periodontitis. Reactive antibody levels were determined using an enzyme-linked immunosorbent assay with whole cell preparations of Bacteroides gingivalis, Capnocytophaga (Bacteroides) ochraceus, Fusobacterium nucleatum and Actinobacillus actinomycetemcomitans (Y-4) serving as antigens. Increased reactivity to B. gingivalis and F. nucleatum was observed in all three disease groups studied while antibody reactive to A. actinomycetemcomitans was increased in juvenile and rapidly progressive periodontitis. Antibody levels reactive to C. ochraceus in healthy subjects did not differ from those observed in any disease patient groups. Possible implications in the etiology and progression of the diseases coupled with environmental changes which occur in the econiche of the periodontal pocket are described.
在182例具有临床特征的患者中测定了对选定牙周病原体的血清抗体水平：35例健康对照者、50例青少年牙周炎患者、42例成人牙周炎患者和55例快速进展性牙周炎患者。使用酶联免疫吸附测定法，以牙龈拟杆菌、黄褐二氧化碳嗜纤维菌（拟杆菌属）、具核梭杆菌和伴放线放线杆菌（Y-4）的全细胞制剂作为抗原，测定反应性抗体水平。在所研究的所有三个疾病组中均观察到对牙龈拟杆菌和具核梭杆菌的反应性增加，而在青少年和快速进展性牙周炎中，对伴放线放线杆菌的抗体反应性增加。健康受试者中对黄褐二氧化碳嗜纤维菌的抗体水平与任何疾病患者组中观察到的水平无差异。描述了这些结果在疾病病因和进展中的可能意义，以及牙周袋生态环境中发生的环境变化。
