Du Lei, Ye Fang, Gao Wenwen, Yang Aocai, Luan Jixin, Xu Manxi, Lv Kuan, Hu Pianpian, Liu Bing, Yu Hongwei, Wang Yuli, Huang Weijie, Shu Ni, Ouyang Gaoxiang, Yin Qian, Shmuel Amir, Wang Yunfeng, Zhang Qi, Xu Pengfei, Ma Guolin
Department of Radiology, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang, Beijing 100029, China.
Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian, Beijing 100142, China.
Cereb Cortex. 2024 May 2;34(13):63-71. doi: 10.1093/cercor/bhae081.
To investigate potential correlations between the susceptibility values of certain brain regions and the severity of disease or neurodevelopmental status in children with autism spectrum disorder (ASD), 18 ASD children and 15 healthy controls (HCs) were recruited. The neurodevelopmental status was assessed by the Gesell Developmental Schedules (GDS) and the severity of the disease was evaluated by the Autism Behavior Checklist (ABC). Eleven brain regions were selected as regions of interest and the susceptibility values were measured by quantitative susceptibility mapping. To evaluate the diagnostic capacity of susceptibility values in distinguishing ASD and HC, the receiver operating characteristic (ROC) curve was computed. Pearson and Spearman partial correlation analysis were used to depict the correlations between the susceptibility values, the ABC scores, and the GDS scores in the ASD group. ROC curves showed that the susceptibility values of the left and right frontal white matter had a larger area under the curve in the ASD group. The susceptibility value of the right globus pallidus was positively correlated with the GDS-fine motor scale score. These findings indicated that the susceptibility value of the right globus pallidus might be a viable imaging biomarker for evaluating the neurodevelopmental status of ASD children.
为了研究自闭症谱系障碍（ASD）儿童特定脑区的磁化率值与疾病严重程度或神经发育状况之间的潜在相关性，招募了18名ASD儿童和15名健康对照（HC）。通过盖塞尔发育量表（GDS）评估神经发育状况，通过自闭症行为量表（ABC）评估疾病严重程度。选择11个脑区作为感兴趣区域，并通过定量磁化率成像测量磁化率值。为了评估磁化率值区分ASD和HC的诊断能力，计算了受试者工作特征（ROC）曲线。采用Pearson和Spearman偏相关分析来描述ASD组中磁化率值、ABC评分和GDS评分之间的相关性。ROC曲线显示，ASD组左右额叶白质的磁化率值在曲线下面积较大。右侧苍白球的磁化率值与GDS精细运动量表评分呈正相关。这些发现表明，右侧苍白球的磁化率值可能是评估ASD儿童神经发育状况的一种可行的影像学生物标志物。
