Department of Otolaryngology and Head&neck, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China; Department of Otolaryngology and Head&neck, China-Japan Union Hospital, Jilin University, Changchun, 130033, China.
School of Life Sciences, Shanghai University, Shanghai, 200444, China.
Comput Biol Med. 2024 Jun;175:108495. doi: 10.1016/j.compbiomed.2024.108495. Epub 2024 Apr 26.
Allergic rhinitis is a common allergic disease with a complex pathogenesis and many unresolved issues. Studies have shown that the incidence of allergic rhinitis is closely related to genetic factors, and research on the related genes could help further understand its pathogenesis and develop new treatment methods. In this study, 446 allergic rhinitis-related genes were obtained on the basis of the DisGeNET database. The protein-protein interaction network was searched using the random-walk-with-restart algorithm with these 446 genes as seed nodes to assess the linkages between other genes and allergic rhinitis. Then, this result was further examined by three screening tests, including permutation, interaction, and enrichment tests, which aimed to pick up genes that have strong and special associations with allergic rhinitis. 52 novel genes were finally obtained. The functional enrichment test confirmed their relationships to the biological processes and pathways related to allergic rhinitis. Furthermore, some genes were extensively analyzed to uncover their special or latent associations to allergic rhinitis, including IRAK2 and MAPK, which are involved in the pathogenesis of allergic rhinitis and the inhibition of allergic inflammation via the p38-MAPK pathway, respectively. The new found genes may help the following investigations for understanding the underlying molecular mechanisms of allergic rhinitis and developing effective treatments.
变应性鼻炎是一种常见的过敏性疾病，其发病机制复杂，有许多尚未解决的问题。研究表明，变应性鼻炎的发病率与遗传因素密切相关，对相关基因的研究有助于进一步了解其发病机制，并开发新的治疗方法。本研究在 DisGeNET 数据库的基础上获得了 446 个与变应性鼻炎相关的基因。然后，使用随机游走重启算法搜索这些 446 个基因作为种子节点的蛋白质-蛋白质相互作用网络，以评估其他基因与变应性鼻炎之间的联系。然后，通过三种筛选测试（置换、相互作用和富集测试）进一步检查该结果，旨在筛选出与变应性鼻炎具有强关联和特殊关联的基因。最终获得了 52 个新基因。功能富集测试证实了它们与变应性鼻炎相关的生物学过程和途径的关系。此外，对一些基因进行了广泛分析，以揭示它们与变应性鼻炎的特殊或潜在关联，包括 IRAK2 和 MAPK，它们分别通过 p38-MAPK 途径参与变应性鼻炎的发病机制和抑制过敏炎症。新发现的基因可能有助于以下研究，以了解变应性鼻炎的潜在分子机制，并开发有效的治疗方法。
