Solaini G, Ronca G, Bertelli A
Drugs Exp Clin Res. 1985;11(2):115-21.
Aclacinomycin, 4'-epi-doxorubicin and 4'-epi-tetrahydropyranyl-adriamycin, three novel anthraquinone derivatives under investigation for their antitumour activity, showed an inhibitory effect on the in vitro respiration of mitochondria from rat hearts. The inhibition proved to be concentration-dependent in the range 0.05 to 1.40 mM and both the NADH-oxidase and the succinate oxidase systems were affected to different extents. Among the compounds tested, 4'-epi-tetrahydropyranyl-adriamycin appeared to be the least powerful effector, requiring a significantly higher concentration for 50% inhibition of oxidation than doxorubicin and the other analogues examined.
阿克拉霉素、4'-表阿霉素和4'-表四氢吡喃基阿霉素这三种正在研究其抗肿瘤活性的新型蒽醌衍生物，对大鼠心脏线粒体的体外呼吸表现出抑制作用。在0.05至1.40 mM范围内，这种抑制作用呈浓度依赖性，并且NADH氧化酶和琥珀酸氧化酶系统均受到不同程度的影响。在所测试的化合物中，4'-表四氢吡喃基阿霉素似乎是作用最弱的效应物，与阿霉素和其他所检测的类似物相比，其抑制氧化作用达50%所需的浓度要高得多。
