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[肉毒杆菌毒素治疗男性下尿路症状(LUTS):我们能期待什么?]

[Botulinum toxin in male lower urinary tract symptoms (LUTS): What can we expect?].

作者信息

Schönburg Sandra

机构信息

Universitätsklinik für Urologie und Nierentransplantation, Martin-Luther-Universität Halle/Saale, Ernst-Grube-Straße 40, 06120, Halle/Saale, Deutschland.

出版信息

Urologie. 2024 Jul;63(7):653-657. doi: 10.1007/s00120-024-02352-0. Epub 2024 May 2.

DOI:10.1007/s00120-024-02352-0
PMID:38698262
Abstract

During the last two decades botulinum toxin has also conquered urology. Botulinum toxin reduces the contractility and sensitivity of the detrusor muscle and relieves pain. It is therefore a promising drug whose use in men also appears promising. The following article highlights the practical relevance of botulinum toxin for male lower urinary tract symptoms (LUTS). But first of all, a distinction must be made between use in male LUTS due to benign prostate syndrome (BPS) and use in cases of overactive bladder (OAB) alone. A differentiated diagnosis and treatment of male LUTS is therefore essential.

摘要

在过去二十年中,肉毒杆菌毒素也在泌尿外科领域得到了应用。肉毒杆菌毒素可降低逼尿肌的收缩力和敏感性,缓解疼痛。因此,它是一种很有前景的药物,在男性患者中的应用似乎也很有前景。以下文章重点介绍了肉毒杆菌毒素对男性下尿路症状(LUTS)的实际应用价值。但首先,必须区分其在良性前列腺综合征(BPS)导致的男性LUTS中的应用和仅在膀胱过度活动症(OAB)病例中的应用。因此,对男性LUTS进行差异化诊断和治疗至关重要。

相似文献

1
[Botulinum toxin in male lower urinary tract symptoms (LUTS): What can we expect?].[肉毒杆菌毒素治疗男性下尿路症状(LUTS):我们能期待什么?]
Urologie. 2024 Jul;63(7):653-657. doi: 10.1007/s00120-024-02352-0. Epub 2024 May 2.
2
An updated systematic review and statistical comparison of standardised mean outcomes for the use of botulinum toxin in the management of lower urinary tract disorders.一项关于使用肉毒杆菌毒素治疗下尿路疾病的标准化均数结局的更新系统评价和统计学比较。
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Eur Urol Focus. 2018 Jan;4(1):17-24. doi: 10.1016/j.euf.2018.04.005. Epub 2018 Apr 14.
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Can Botulinum Toxin A Still Have a Role in Treatment of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Through Inhibition of Chronic Prostatic Inflammation?A型肉毒杆菌毒素能否通过抑制慢性前列腺炎仍在治疗下尿路症状/良性前列腺增生中发挥作用?
Toxins (Basel). 2019 Sep 19;11(9):547. doi: 10.3390/toxins11090547.
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Clinical application of intravesical botulinum toxin type A for overactive bladder and interstitial cystitis.经尿道注射肉毒毒素 A 治疗膀胱过度活动症和间质性膀胱炎的临床应用。
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Botulinum toxin injections for adults with overactive bladder syndrome.肉毒杆菌毒素注射治疗成人膀胱过度活动症
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Botulinum toxin injection for lower urinary tract dysfunction.肉毒毒素注射治疗下尿路功能障碍。
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Botulinum toxin type A for the treatment of lower urinary tract disorders.A型肉毒毒素治疗下尿路疾病。
Int J Urol. 2012 Mar;19(3):202-15. doi: 10.1111/j.1442-2042.2011.02946.x. Epub 2012 Jan 6.

本文引用的文献

1
Clinical Application of Botulinum Neurotoxin in Lower-Urinary-Tract Diseases and Dysfunctions: Where Are We Now and What More Can We Do?肉毒毒素在治疗下尿路疾病和功能障碍中的临床应用:我们现在在哪里,还能做些什么?
Toxins (Basel). 2022 Jul 18;14(7):498. doi: 10.3390/toxins14070498.
2
Long-term Follow-up of Intravesical Onabotulinum Toxin-A Injections in Male Patients with Idiopathic Overactive Bladder: Comparing Surgery-naïve Patients and Patients After Prostate Surgery.男性特发性逼尿症患者膀胱内注射肉毒毒素 A 的长期随访:比较未手术患者和前列腺手术后患者。
Eur Urol Focus. 2021 Nov;7(6):1424-1429. doi: 10.1016/j.euf.2020.08.015. Epub 2020 Sep 9.
3
Diagnostic Assessment of Lower Urinary Tract Symptoms in Men Considering Prostate Surgery: A Noninferiority Randomised Controlled Trial of Urodynamics in 26 Hospitals.
考虑前列腺手术的男性下尿路症状的诊断评估:26 家医院的尿动力学非劣效随机对照试验。
Eur Urol. 2020 Nov;78(5):701-710. doi: 10.1016/j.eururo.2020.06.004. Epub 2020 Jun 30.
4
Transperineal intraprostatic injection of botulinum neurotoxin A vs transurethral resection of prostate for management of lower urinary tract symptoms secondary to benign prostate hyperplasia: A prospective randomised study.经会阴前列腺内注射A型肉毒杆菌神经毒素与经尿道前列腺切除术治疗良性前列腺增生继发下尿路症状的前瞻性随机研究。
Arab J Urol. 2019 Oct 3;17(4):270-278. doi: 10.1080/2090598X.2019.1662214. eCollection 2019.
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Where can urodynamic testing help assess male lower urinary tract symptoms?尿动力学检查可在哪些方面帮助评估男性下尿路症状?
Turk J Urol. 2019 Feb 5;45(3):157-163. doi: 10.5152/tud.2019.82783. Print 2019 May.
6
The International Continence Society (ICS) report on the terminology for adult male lower urinary tract and pelvic floor symptoms and dysfunction.国际尿控协会(ICS)关于成人男性下尿路和盆底症状及功能障碍术语的报告。
Neurourol Urodyn. 2019 Feb;38(2):433-477. doi: 10.1002/nau.23897. Epub 2019 Jan 25.
7
Best practice in the management of storage symptoms in male lower urinary tract symptoms: a review of the evidence base.男性下尿路症状储尿期症状管理的最佳实践:循证综述
Ther Adv Urol. 2017 Dec 7;10(2):79-92. doi: 10.1177/1756287217742837. eCollection 2018 Feb.
8
Prostatic injection of botulinum toxin is not inferior to optimized medical therapy in the management of lower urinary tract symptoms due to benign prostatic hyperplasia: results of a randomized clinical trial.经尿道前列腺注射肉毒毒素治疗良性前列腺增生所致下尿路症状与优化药物治疗的随机临床试验结果:不劣效性分析。
World J Urol. 2018 Jun;36(6):921-929. doi: 10.1007/s00345-018-2193-y. Epub 2018 Jan 30.
9
The Efficacy and Safety of OnabotulinumtoxinA or Solifenacin Compared with Placebo in Solifenacin Naïve Patients with Refractory Overactive Bladder: Results from a Multicenter, Randomized, Double-Blind Phase 3b Trial.在索利那新初治的难治性膀胱过度活动症患者中,与安慰剂相比,肉毒毒素 A 或索利那新的疗效和安全性:一项多中心、随机、双盲 3b 期试验的结果。
J Urol. 2017 Jul;198(1):167-175. doi: 10.1016/j.juro.2017.01.069. Epub 2017 Feb 1.
10
Randomized, double-blind, placebo controlled pilot study of intradetrusor injections of onabotulinumtoxinA for the treatment of refractory overactive bladder persisting following surgical management of benign prostatic hyperplasia.一项关于膀胱内注射A型肉毒杆菌毒素治疗良性前列腺增生手术治疗后持续存在的难治性膀胱过度活动症的随机、双盲、安慰剂对照试验研究。
Can J Urol. 2014 Apr;21(2):7217-21.