Lin Haishan, Cao Bangwei
Cancer Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Genet. 2024 Apr 18;15:1282471. doi: 10.3389/fgene.2024.1282471. eCollection 2024.
Prior observational studies have suggested an association between circulating vascular endothelial growth factor (VEGF) levels and inflammatory bowel disease (IBD). This study sought to demonstrate the directionality of the association between circulating VEGF and particular forms of IBD as well as if there is a causal relationship between them. We collected summary data from relevant genome-wide association studies (GWASs) to assess the validity of causality, and a two-sample bidirectional Mendelian randomization (MR) study and sensitivity testing were performed to assess the causal relationship between circulating VEGF and IBD risk, including Crohn's disease and ulcerative colitis. Our findings revealed a direct causal link between circulating VEGF and Crohn's disease (b 0.195, se 0.078, < 0.013). However, neither circulating VEGF nor ulcerative colitis were shown to be causally linked ( > 0.025), nor was there proof of a reverse causal relationship from IBD to VEGF. In conclusion, circulating VEGF shows a cause-and-effect relationship with Crohn's disease.
先前的观察性研究表明，循环血管内皮生长因子（VEGF）水平与炎症性肠病（IBD）之间存在关联。本研究旨在证明循环VEGF与特定形式的IBD之间关联的方向性，以及它们之间是否存在因果关系。我们收集了相关全基因组关联研究（GWAS）的汇总数据以评估因果关系的有效性，并进行了两样本双向孟德尔随机化（MR）研究和敏感性测试，以评估循环VEGF与IBD风险（包括克罗恩病和溃疡性结肠炎）之间的因果关系。我们的研究结果揭示了循环VEGF与克罗恩病之间存在直接因果联系（b 0.195，标准误0.078，P<0.013）。然而，循环VEGF与溃疡性结肠炎均未显示出因果联系（P>0.025），也没有证据表明存在从IBD到VEGF的反向因果关系。总之，循环VEGF与克罗恩病存在因果关系。
