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前外阴切除及远端尿道切除术后应用双侧新加坡筋膜皮瓣修复局限性复发性外阴癌。

Bilateral Singapore fasciocutaneous flap after anterior vulvectomy and distal urethrectomy for localized recurrent vulvar carcinoma.

作者信息

Crum Madison, Miller Caela, Micallef Christopher, Delaney Richard, Hope Erica

机构信息

Department of Gynecologic Surgery and Obstetrics, San Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Dr, Fort Sam Houston, TX 78234, USA.

Department of Plastic Surgery, San Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Dr, Fort Sam Houston, TX 78234, USA.

出版信息

Gynecol Oncol Rep. 2024 Apr 15;53:101373. doi: 10.1016/j.gore.2024.101373. eCollection 2024 Jun.

Abstract

INTRODUCTION

Vulvar cancer has an overall low incidence, accounting for approximately 3-5% of all gynecological malignancies.Case: We present a case of locally recurrent Stage IIIA squamous cell carcinoma of the vulva in a 51-year-old healthy African American female. She was initially treated with primary chemoradiation with cisplatin sensitization and boost to primary tumor up to 70 Gray. Post-treatment biopsies revealed complete pathologic response. She later presented with local recurrence to the primary site of the clitoris and vulva, with no evidence of metastasis on imaging, with progressive disease despite treatment with immunotherapy.

METHODS

Biopsy-proven disease progression was present on the clitoris, entire left labia minora, and a portion of the right labia minora with no evidence of metastasis on imaging. Surgical resection for localized recurrence was recommended, and she underwent radical anterior vulvectomy, distal urethrectomy, and vulvar reconstruction with bilateral Singapore fasciocutaneous flap as part of a multidisciplinary team. Patient underwent several prophylactic hyperbaric oxygen treatments. There were no issues with postoperative wound healing.

CONCLUSION

Treatment with radical excision often requires multidisciplinary teams for complex reconstructions to restore vulvar anatomy in the setting of prior radiation, especially for those patients desiring the ability to have penetrative intercourse in the future. There are few surgical videos that describe these types of vulvar excisions and subsequent reconstructions. This video provides a unique approach to vulvar reconstruction in a previously irradiated field.

摘要

引言

外阴癌的总体发病率较低,约占所有妇科恶性肿瘤的3%-5%。

病例

我们报告一例51岁健康非裔美国女性的局部复发性外阴III A期鳞状细胞癌。她最初接受了以顺铂增敏的原发放化疗,对原发肿瘤的照射剂量增加至70格雷。治疗后的活检显示病理完全缓解。她后来出现了阴蒂和外阴原发部位的局部复发,影像学检查未发现转移迹象,尽管接受了免疫治疗,但病情仍进展。

方法

活检证实疾病进展存在于阴蒂、整个左侧小阴唇和右侧小阴唇的一部分,影像学检查未发现转移迹象。建议对局部复发进行手术切除,她作为多学科团队的一部分接受了根治性前部外阴切除术、远端尿道切除术以及双侧新加坡筋膜皮瓣外阴重建术。患者接受了多次预防性高压氧治疗。术后伤口愈合没有问题。

结论

根治性切除术的治疗通常需要多学科团队进行复杂的重建,以在先前放疗的情况下恢复外阴解剖结构,特别是对于那些未来希望能够进行穿透性性交的患者。很少有手术视频描述这类外阴切除术及后续重建。本视频提供了一种在先前放疗区域进行外阴重建的独特方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af6/11063377/a42897d92030/gr1.jpg

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