血清突触素样1蛋白水平在乳腺癌中的临床意义
Clinical significance of serum synaptophysin-like 1 protein levels in breast cancer.
作者信息
Kosem Yagmur Ozge Turac, Uzun Hafize, Velidedeoglu Mehmet, Kocael Pınar, Dumur Seyma, Simsek Osman
机构信息
Istanbul University-Cerrahpas, Cerrahpa a Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.
Istanbul Atlas University, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey.
出版信息
J Med Biochem. 2024 Apr 23;43(2):273-280. doi: 10.5937/jomb0-46198.
BACKGROUND
Mammography, used for breast cancer (BC) screening, has limitations such as decreased sensitivity in dense breasts. Currently used tumor markers are insufficient in diagnosing breast cancer. In this study, we aimed to investigate the relationship between serum levels of synaptophysin-like protein 1 (SYPL1) and BC and compare SYPL1 with other blood tumor markers.
METHODS
The study group consisted of 80 female patients with a histopathological diagnosis of invasive BC who received no radiotherapy/chemotherapy. The control group was 72 women with no previous history of breast disease and evaluated as Breast Imaging Reporting and Data Systems (BI-RADS 1-2) on imaging. Serum SYPL1, cancer antigen 15-3 (CA 15-3), and carcinoembryonic antigen (CEA) were measured in both groups.
背景
用于乳腺癌（BC）筛查的乳腺X线摄影存在局限性，如在致密型乳腺中敏感性降低。目前使用的肿瘤标志物在乳腺癌诊断中并不充分。在本研究中，我们旨在探讨血清突触素样蛋白1（SYPL1）水平与乳腺癌之间的关系，并将SYPL1与其他血液肿瘤标志物进行比较。
方法
研究组由80例经组织病理学诊断为浸润性乳腺癌且未接受放疗/化疗的女性患者组成。对照组为72名既往无乳腺疾病史且影像学评估为乳腺影像报告和数据系统（BI-RADS 1-2）的女性。两组均检测血清SYPL1、癌抗原15-3（CA 15-3）和癌胚抗原（CEA）。
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