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CA125、CA153和CEA在乳腺癌患者乳头溢液中的表达及临床意义

Expression and clinical significance of CA125, CA153 and CEA in nipple discharge of breast cancer patients.

作者信息

Geng Jun, Jinli Shi, Guo Weina, Li Haiyan, Dan Yang, Gao Yan

机构信息

Jinan Central Hospital, Medical Laboratory Diagnosis Center, Jinan, China.

Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Emergency Center, Qingdao, China.

出版信息

J Med Biochem. 2024 Apr 23;43(2):234-242. doi: 10.5937/jomb0-45192.

DOI:10.5937/jomb0-45192
PMID:38699697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11062330/
Abstract

BACKGROUND

It is an important clinical means to identify benign and malignant breast diseases caused by nipple discharge through the detection and analysis of components in nipple discharge. This study was aimed to test the expression and clinical significance of carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153) and carcinoembryonic antigen (CEA) in nipple discharge of breast cancer patients.

METHODS

From January 2017 to December 2018, 86 patients with invasive ductal carcinoma of the breast with nipple discharge (breast cancer group) and 50 patients with ordinary breast duct hyperplasia with nipple discharge (benign control group) were selected, and the levels of CA125, CA153 and CEA in nipple discharge and serum were detected by electrochemiluminescence immunoassay.

摘要

背景

通过对乳头溢液成分的检测与分析来鉴别由乳头溢液引起的乳腺良恶性疾病是一项重要的临床手段。本研究旨在检测糖类抗原125（CA125）、糖类抗原153（CA153）和癌胚抗原（CEA）在乳腺癌患者乳头溢液中的表达及临床意义。

方法

选取2017年1月至2018年12月期间86例伴有乳头溢液的乳腺浸润性导管癌患者（乳腺癌组）和50例伴有乳头溢液的普通乳腺导管增生患者（良性对照组），采用电化学发光免疫分析法检测乳头溢液及血清中CA125、CA153和CEA的水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0c/11062330/6e490f8670df/jomb-43-2-2402234G_g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0c/11062330/8a431892a34f/jomb-43-2-2402234G_g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0c/11062330/6e490f8670df/jomb-43-2-2402234G_g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0c/11062330/8a431892a34f/jomb-43-2-2402234G_g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0c/11062330/6e490f8670df/jomb-43-2-2402234G_g002.jpg

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