湖南省不同类型地中海贫血携带者筛查指标的比较
Comparison of screening indicators for different types of thalassemia carriers in Hunan Province.
作者信息
Tang Hua, Yu Rong, Yu Ziyin, Xi Hui
机构信息
Maternal and Child Health Hospital of Hunan Province, Department of Medical Genetic, Changsha City, Hunan Province, China.
University of South China, The Affiliated Changsha Central Hospital, Hengyang Medical School, Department of Laboratory, Changsha City, Hunan Province, China.
出版信息
J Med Biochem. 2024 Apr 23;43(2):281-289. doi: 10.5937/jomb0-46085.
BACKGROUND
Carrier screening is the most effective method to block the occurrence of thalassemia. However, due to differences in race and genotype, MCV, MCH, HbA2 and other indicators are far from each other. The purpose of this study is to evaluate the common screening indicators of a, b and ab-compound thalassemia carriers in Hunan Province, and try to use the relevant formulas in the existing literature to predict and distinguish different types of thalassemia carriers.
METHODS
Receiver operating characteristic curve (ROC curve) combined with Youden index was utilized to analyze results of blood routine examination, hemoglobin electrophoresis, and literature-related formulas for 1111 a-thalassemia carriers, 464 b-thalassemia carriers and 24 ab-thalassemia carriers.
背景
携带者筛查是阻断地中海贫血发生的最有效方法。然而，由于种族和基因型的差异，平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）、血红蛋白A2（HbA2）等指标差异较大。本研究旨在评估湖南省α、β和αβ复合型地中海贫血携带者的常见筛查指标，并尝试运用现有文献中的相关公式预测和区分不同类型的地中海贫血携带者。
方法
采用受试者工作特征曲线（ROC曲线）结合约登指数，对1111例α地中海贫血携带者、464例β地中海贫血携带者和24例αβ复合型地中海贫血携带者的血常规检查、血红蛋白电泳结果及文献相关公式进行分析。
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