Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Obes Rev. 2024 Aug;25(8):e13763. doi: 10.1111/obr.13763. Epub 2024 May 3.
Obesity is among the most common chronic disorders, worldwide. It is a complex disease that reflects the interactions between environmental influences, multiple genetic allelic variants, and behavioral factors. Recent developments have also shown that biological conditions in utero play an important role in the programming of energy homeostasis systems and might have an impact on obesity and metabolic disease risk. The corticotropin-releasing hormone (CRH) family of neuropeptides, as a central element of energy homeostasis, has been evaluated for its role in the pathophysiology of obesity. This review aims to summarize the relevance and effects of the CRH family of peptides in the pathophysiology of obesity spanning from fetal life to adulthood.
肥胖症是全球最常见的慢性疾病之一。它是一种复杂的疾病，反映了环境影响、多种基因等位变体和行为因素之间的相互作用。最近的研究还表明，子宫内的生物条件在能量平衡系统的编程中起着重要作用，并可能对肥胖和代谢性疾病的风险产生影响。促肾上腺皮质激素释放激素（CRH）家族神经肽作为能量平衡的一个中心要素，其在肥胖症的病理生理学中的作用已经得到了评估。本综述旨在总结 CRH 家族肽在肥胖症的病理生理学中的相关性和作用，涵盖了从胎儿期到成年期的各个阶段。
