Department of Urology, Al-Azhar University, Cairo.
Department of Dermatology & Andrology, Al-Azhar University, Cairo.
Arch Ital Urol Androl. 2024 May 2;96(2):12323. doi: 10.4081/aiua.2024.12323.
This study aims to investigate the current evidence regarding the impact of oral antioxidant supplementation on semen parameters of infertile men.
We conducted a systematic search of PubMed, and Cochrane electronic databases, adhering to modified Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The focus was on studies exploring the effects of antioxidant therapy on infertile men, with an examination of antioxidants in terms of types, doses, rationale for use, and their impact on semen parameters measures.
A total of 18 studies that met the inclusion criteria were included in this study. Out of these, 14 studies reported a significantly positive influence of antioxidant therapy on basic semen parameters and advanced sperm function. These comprised 11 randomized clinical trials and 7 prospective studies. Commonly utilized antioxidants included Vitamin E, Vitamin C, carnitines, co-enzyme Q10, N-acetyl cysteine, zinc, selenium, folic acid, and lycopene.
Overall, antioxidants generally demonstrate a favorable effect on semen parameters of infertile men. However, further research is necessary to pinpoint the optimal antioxidant regimen that can be applied safely and effectively in clinical practice.
本研究旨在探讨口服抗氧化补充剂对不育男性精液参数的影响的现有证据。
我们按照改良的系统评价和荟萃分析（PRISMA）指南，对 PubMed 和 Cochrane 电子数据库进行了系统检索。研究重点是探索抗氧化剂治疗对不育男性影响的研究，考察了抗氧化剂的类型、剂量、使用理由以及它们对精液参数测量的影响。
共有 18 项符合纳入标准的研究纳入本研究。其中 14 项研究报告抗氧化治疗对基础精液参数和先进精子功能有显著积极影响。这些研究包括 11 项随机临床试验和 7 项前瞻性研究。常用的抗氧化剂包括维生素 E、维生素 C、肉碱、辅酶 Q10、N-乙酰半胱氨酸、锌、硒、叶酸和番茄红素。
总体而言，抗氧化剂通常对不育男性的精液参数有有利影响。然而，仍需要进一步研究以确定在临床实践中安全有效应用的最佳抗氧化方案。
