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加勒比地区听力损失的遗传图谱:一项叙述性综述。

Genetic Landscape of Hearing Loss in the Caribbean: A Narrative Review.

作者信息

Peart LéShon, Tekin Mustafa

机构信息

Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.

John P. Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.

出版信息

Balkan Med J. 2024 May 3;41(3):161-166. doi: 10.4274/balkanmedj.galenos.2024.2024-2-110.

Abstract

The Caribbean region has a diverse population of about 40 million people, spread over 13 sovereign states. This review aims to describe the existing studies on hereditary hearing loss (HL) in the Caribbean population. We systematically reviewed scientific articles on HL prevalence, genetic causes, technology use, and environmental effects in Caribbean nations and the Caribbean diaspora in the United States. Key findings show that HL rates, with diverse genetic variables, vary across Puerto Rico, Cuba, and the Dominican Republic. Local resources and technology have been used to diagnose HL, particularly in rural areas. Environmental factors tend to affect HL prevalence in various regions. This literature review of Caribbean-focused studies helps guide future research and healthcare strategies, particularly concerning genetic drift caused by migration to the United States. Understanding these factors can help diagnose and treat HL in America's diverse population.

摘要

加勒比地区人口约4000万,分布在13个主权国家,人口构成多样。本综述旨在描述加勒比人群中关于遗传性听力损失(HL)的现有研究。我们系统地回顾了关于加勒比国家以及美国加勒比侨民中HL患病率、遗传原因、技术应用和环境影响的科学文章。主要研究结果表明,由于遗传变量不同,波多黎各、古巴和多米尼加共和国的HL发病率各不相同。当地资源和技术已被用于诊断HL,尤其是在农村地区。环境因素往往会影响不同地区的HL患病率。这篇以加勒比地区为重点的文献综述有助于指导未来的研究和医疗保健策略,特别是关于移民到美国导致的基因漂变。了解这些因素有助于诊断和治疗美国多样化人群中的HL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5753/11077928/6cb7caa9733f/BMJ-41-161-g1.jpg

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