感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）德尔塔和奥密克戎变体的新冠肺炎患者症状比较——德国国家大流行队列网络跨部门平台（NAPKON-SUEP）的结果
Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron-results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP).
作者信息
Hopff Sina M, Appel Katharina S, Miljukov Olga, Schneider Johannes, Addo Marylyn M, Bals Robert, Bercker Sven, Blaschke Sabine, Bröhl Isabel, Büchner Nikolaus, Dashti Hiwa, Erber Johanna, Friedrichs Anette, Geisler Ramsia, Göpel Siri, Hagen Marina, Hanses Frank, Jensen Björn-Erik Ole, Keul Maria, Krawczyk Adalbert, Lorenz-Depiereux Bettina, Meybohm Patrick, Milovanovic Milena, Mitrov Lazar, Nürnberger Carolin, Obst Wilfried, Römmele Christoph, Schäfer Christian, Scheer Christian, Scherer Margarete, Schmidt Julia, Seibel Kristina, Sikdar Shimita, Tebbe Johannes Josef, Tepasse Phil-Robin, Thelen Philipp, Vehreschild Maria J G T, Weismantel Christina, Vehreschild J Janne
机构信息
Faculty of Medicine, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, University Hospital Cologne, Weißhausstraße 24, 50939, Cologne, Germany.
Center for Internal Medicine, Medical Department 2 (Hematology/Oncology and Infectious Diseases), Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
出版信息
Infection. 2024 Dec;52(6):2253-2267. doi: 10.1007/s15010-024-02270-5. Epub 2024 May 3.
PURPOSE
The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron.
METHODS
We compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points.
RESULTS
We considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95% CI 0.73-0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron.
CONCLUSION
With quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU.
CLINICAL TRAIL REGISTRATION
The cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).
目的
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体对新冠后状况（PCC）的影响仍未明确。因此，我们研究了感染SARS-CoV-2变体德尔塔或奥密克戎的患者中PCC相关症状的患病率及预测因素。
方法
我们比较了德国国家大流行队列网络跨部门平台中感染德尔塔和奥密克戎的患者在初次感染后三个月（3MFU）时急性症状和PCC相关症状的患病率及危险因素。通过EQ-5D-5L指数评分确定健康相关生活质量（HrQoL），并计算趋势组以描述不同时间点之间HrQoL的变化。
结果
我们纳入758例患者进行分析（德尔塔组：n = 341；奥密克戎组：n = 417）。与奥密克戎组患者相比，德尔塔组患者在3MFU时PCC的患病率相似（p = 0.354），其中疲劳最为常见（n = 256，34%）。两组在疾病发作时EQ-5D-5L指数评分最低（0.75，95%CI 0.73 - 0.78），此时HrQoL相当。虽然大多数患者（69%，n = 348）的HrQoL从未下降，但从急性期到3MFU时，有37例患者（7%）的HrQoL显著恶化，其中27例感染的是奥密克戎。
结论
通过多中心队列的质量控制数据，我们表明至少对于德国人群，PCC对于感染SARS-CoV-2变体德尔塔和奥密克戎的患者来说是同样常见的挑战。通过计算EQ-5D-5L指数评分趋势组表明，超过三分之二的患者在3MFU时并未因SARS-CoV-2感染或感染后而在HrQoL方面受到任何限制。
临床试验注册
该队列自2021年2月24日起在ClinicalTrials.gov注册（标识符：NCT04768998）。
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