Utekhin V I
Arkh Anat Gistol Embriol. 1979 Sep;77(9):79-86.
The effect of prolonged thyroxine administration (0.001 mg/g BW) on pancreatic islets has been studied on 64 Wistar male rats by means of radioautographic, morphometric and electron microscopic methods. The phase response in the amount of the DNA-synthesising cells of the middle class islets has been revealed: the initial increase (5 days) is followed by a decrease (30 days) and then by a return to the control levels (60 days). The level of metabolism in sulphur-containing proteins has decreased in both A- and B-cells. After 30 days of the experiment, B/A cell volume ratio has been shown to increase. Electron microscopic studies have revealed ultrastructural reorganization of B-cells from "resting" B-cells into "dark" B-cells at increased excretion of secretory material.
通过放射自显影、形态计量和电子显微镜方法，对64只雄性Wistar大鼠研究了长期给予甲状腺素（0.001mg/g体重）对胰岛的影响。已揭示中等大小胰岛中DNA合成细胞数量的阶段性反应：最初增加（5天），随后减少（30天），然后恢复到对照水平（60天）。A细胞和B细胞中含硫蛋白质的代谢水平均降低。实验30天后，B/A细胞体积比增加。电子显微镜研究显示，随着分泌物质排泄增加，B细胞从“静止”B细胞超微结构重组成“暗”B细胞。
