Scripps Cancer Center, San Diego, California, USA.
J Appl Clin Med Phys. 2024 Jun;25(6):e14379. doi: 10.1002/acm2.14379. Epub 2024 May 3.
A novel pulse normalization technology enabling the acquisition of low noise beam data without the use of a physical reference chamber has recently been commercially released. The purpose of this study was to characterize the use of this technology for beam scanning of small fields required in the commissioning of a stereotactic radiotherapy program.
Three detectors (Edge diode, microDiamond, PinPoint) were used to acquire beam data under three conditions: with a reference chamber, with pulse normalization and no reference chamber (PN), and without pulse normalization and no reference chamber (nPN). Percent depth dose (PDD) scans were acquired for 0.5, 1.0, 2.0, and 3.0 cm field sizes and profiles were acquired at 1.4, 10, and 30 cm depths using continuous scanning. The coefficient of variation (CoV) was calculated for all beam data to compare signal-to-noise and gamma comparisons (1%, 1 mm) were calculated of the PN and nPN scans compared to the reference data.
Average 95th percentile CoV values were similar for all detectors across conditions, with PN data being comparable to reference data and minor increases observed for nPN data. Mean gamma pass rates for PN PDD scans exceeded 98% for all detectors. Profile gamma pass rates were 100% for all detectors at 1.4 and 10 cm depth. At 30 cm depth, profiles acquired with the PinPoint and microDiamond detectors had lower mean gamma pass rates than the Edge, at 95% and 95.7%, respectively.
A novel pulse normalization technology was demonstrated to be effective for acquiring beam profiles and PDDs for small fields without the use of a physical reference chamber. Limitations in how the method is implemented led to some errors in data acquired using lower sensitivity detectors. When used with a diode, pulse normalization produced equivalent scans to those acquired with a reference chamber.
最近,一种新的脉冲归一化技术已商业化推出,该技术无需使用物理参考腔即可获取低噪声束数据。本研究的目的是研究该技术在立体定向放射治疗计划调试中小野扫描中的应用。
使用三个探测器(边缘二极管、微金刚石、PinPoint)在三种情况下获取束数据:使用参考腔、使用脉冲归一化和无参考腔(PN)以及不使用脉冲归一化和无参考腔(nPN)。获取 0.5、1.0、2.0 和 3.0 cm 射野大小的百分深度剂量(PDD)扫描,并使用连续扫描在 1.4、10 和 30 cm 深度获取射野轮廓。计算所有束数据的变异系数(CoV)以比较信号噪声比,并对 PN 和 nPN 扫描与参考数据进行伽马比较(1%,1mm)。
在所有条件下,所有探测器的平均 95%百分位 CoV 值相似,PN 数据与参考数据相当,nPN 数据略有增加。所有探测器的 PN PDD 扫描的平均伽马通过率均超过 98%。在 1.4 和 10 cm 深度,所有探测器的射野轮廓伽马通过率均为 100%。在 30 cm 深度,PinPoint 和 microDiamond 探测器获取的射野轮廓的平均伽马通过率低于 Edge,分别为 95%和 95.7%。
一种新的脉冲归一化技术被证明可有效获取无物理参考腔的小射野的束轮廓和 PDD。该方法的实施方式存在一些限制,导致使用低灵敏度探测器获取的数据存在一些误差。当与二极管一起使用时,脉冲归一化产生的扫描与使用参考腔获取的扫描相当。