Barsotti G, Abramo F, Nuti M, Novelli A, Puccinelli C, Cecchi F
Department of Veterinary Sciences, University of Pisa, Pisa, Italy.
San Concordio Veterinary Hospital, Lucca, Italy.
Vet Ophthalmol. 2024 Nov;27(6):558-570. doi: 10.1111/vop.13221. Epub 2024 May 3.
To describe multiple congenital ocular anomalies in three litters of Jack Russell Terrier puppies.
Seven purebred Jack Russell Terrier puppies from three related litters and their four parents.
Medical records of the puppies and their parents were evaluated. All dogs underwent a complete ophthalmic examination, followed by bilateral ocular ultrasonography in two of the puppies with complete corneal opacity. One eye from an affected puppy was subjected to histopathology. A complete database of pedigrees was built, and individual inbreeding was evaluated.
The most commonly diagnosed ocular anomalies in the puppies were: various anomalies of the fundus (12/14 eyes); microphthalmia (10/14 eyes); sclerocornea (8/14 eyes); and persistent pupillary membranes (7/14 eyes). Six out of seven puppies had at least two ocular abnormalities, and only one puppy was normal. Four out of seven puppies had sclerocornea, a particular corneal opacity to date described only in Spanish Podenco dogs. No ocular abnormalities were found in the parents examined (4/4). Analysis of the pedigrees showed that all the puppies and two parents were inbred, and the individual values of the inbreeding puppies were greater than 6.25% in two litters.
Inbreeding with closely related Jack Russell Terriers may result in severe congenital eye abnormalities in puppies.
描述三窝杰克罗素梗幼犬的多种先天性眼部异常。
来自三窝相关幼犬的7只纯种杰克罗素梗幼犬及其4只父母。
评估幼犬及其父母的病历。所有犬只均接受了全面的眼科检查，其中2只角膜完全混浊的幼犬随后接受了双眼眼部超声检查。对1只患病幼犬的一只眼睛进行了组织病理学检查。建立了完整的系谱数据库，并评估了个体近亲繁殖情况。
幼犬中最常诊断出的眼部异常为：各种眼底异常（14只眼中的12只）；小眼球（14只眼中的10只）；巩膜角膜（14只眼中的8只）；以及永存瞳孔膜（14只眼中的7只）。7只幼犬中有6只至少有两种眼部异常，只有1只幼犬正常。7只幼犬中有4只患有巩膜角膜，这是一种迄今为止仅在西班牙波登可犬中描述过的特殊角膜混浊。在接受检查的父母（4只）中未发现眼部异常。系谱分析表明，所有幼犬和2只父母均为近亲繁殖，两窝幼犬的个体近亲繁殖值均大于6.25%。
与亲缘关系密切的杰克罗素梗近亲繁殖可能导致幼犬出现严重的先天性眼部异常。
