eIF4G 作为热休克 mRNA 翻译的开关。

eIF4G as a switch for heat shock mRNA translation.

机构信息

Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.

出版信息

Mol Cell. 2024 May 2;84(9):1633-1634. doi: 10.1016/j.molcel.2024.04.002.

DOI:10.1016/j.molcel.2024.04.002

PMID:38701739

Abstract

The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al. demonstrate that a temperature-induced conformational change in the translation initiation factor eIF4G is a key mechanism regulating translation during the heat shock response.

摘要

热休克反应对于细胞存活至关重要。在本期《分子细胞》中，Desroches Altamirano 等人证明，翻译起始因子 eIF4G 在温度诱导下的构象变化是调节热休克反应期间翻译的关键机制。