Ye Sheng, Jiang Yuan, Lu Zhaie
Altern Ther Health Med. 2024 May 3.
Preeclampsia (PE) is a fundamental cause of preterm labor, intrauterine growth restriction, and persistent postpartum hypertension. In the present study, we aimed to investigate the correlation between 24-h urinary protein excretion, serum markers, and placental growth factor and their adverse pregnancy outcomes in patients with PE.
A total of 126 pregnant women with PE (86 cases of mild PE and 40 cases of severe PE, assigned to the observation group) who came to our hospital from March 2019 to December 2021 for regular obstetric checkups and delivery were selected, with 60 healthy pregnant women assigned to the control group. Routine biochemical parameters, 24-h urinary protein quantification, serum parameters, and placental growth factor levels were recorded. The incidence of adverse neonatal pregnancy outcomes and abnormal fetal heart monitoring, neonatal body mass, 1 min Apgar score, and other adverse pregnancy outcomes were also analyzed in the different groups.
In comparison with healthy pregnant subjects, PE patients had earlier delivery gestational weeks (P < .05), significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), 24-h urinary protein excretion, total cholesterol (TC), triglyceride (TG), D-Dimer and human chorionic gonadotropin (β-hCG) levels (P < .05), lower albumin (ALB), platelet count, pregnant associated plasma protein A (PAPP-A) and placental growth factor (PLGF) (P < .05), and higher incidence of maternal and perinatal adverse outcomes (P < .05).
Combined screening of 24-h urinary protein, PAPP-A, β-hCG, PLGF, and serum indicators in early pregnancy are essential in predicting PE, allowing timely assessment of the risk of adverse pregnancy, and providing a basis for clinical intervention.
子痫前期（PE）是早产、胎儿生长受限和产后持续性高血压的根本原因。在本研究中，我们旨在探讨子痫前期患者24小时尿蛋白排泄、血清标志物和胎盘生长因子之间的相关性及其不良妊娠结局。
选取2019年3月至2021年12月来我院进行定期产科检查和分娩的126例子痫前期孕妇（轻度子痫前期86例，重度子痫前期40例，归入观察组），并选取60例健康孕妇作为对照组。记录常规生化参数、24小时尿蛋白定量、血清参数和胎盘生长因子水平。还分析了不同组中不良新生儿妊娠结局的发生率、异常胎心监护、新生儿体重、1分钟阿氏评分及其他不良妊娠结局。
与健康孕妇相比，子痫前期患者分娩孕周更早（P<.05），收缩压（SBP）、舒张压（DBP）、24小时尿蛋白排泄、总胆固醇（TC）、甘油三酯（TG）、D-二聚体和人绒毛膜促性腺激素（β-hCG）水平显著更高（P<.05），白蛋白（ALB）、血小板计数、妊娠相关血浆蛋白A（PAPP-A）和胎盘生长因子（PLGF）更低（P<.05），母婴围产期不良结局发生率更高（P<.05）。
孕早期联合筛查24小时尿蛋白、PAPP-A、β-hCG、PLGF和血清指标对于预测子痫前期至关重要，能够及时评估不良妊娠风险，并为临床干预提供依据。
