Li Wenjie, Wang Wei
Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Sleep Breath. 2024 Aug;28(4):1771-1776. doi: 10.1007/s11325-024-03046-9. Epub 2024 May 4.
Observational studies have suggested that obstructive sleep apnea (OSA) may have a potential carcinogenic role. However, the results of these studies were inconsistent and the underlying genetic mechanisms have yet to be fully understood.
We conducted a Mendelian randomization (MR) analysis using large-scale genome-wide association studies summary statistics to explore the possible causal effect of OSA on the risk of 16 specific-site cancers in the European population.
The MR analysis revealed a significantly negative correlation between OSA and the susceptibility to prostate cancer (OR: 0.87, 95%CI 0.79-0.95, p = 0.002) and a causal increase in the vulnerability to pancreatic malignancies (OR: 2.02, 95%CI 1.1-3.7, p = 0.02). However, no causal effects of OSA on other specific-site cancers were found. Sensitivity analyses demonstrated no significant heterogeneity or horizontal pleiotropy, thus validating the robustness of the original results.
Our MR provided important insights into the causal associations between OSA and cancer risk, highlighting both protective and potentially harmful effects of OSA on different cancer types.
观察性研究表明，阻塞性睡眠呼吸暂停（OSA）可能具有潜在的致癌作用。然而，这些研究的结果并不一致，其潜在的遗传机制尚未完全明确。
我们利用大规模全基因组关联研究的汇总统计数据进行孟德尔随机化（MR）分析，以探究OSA对欧洲人群16种特定部位癌症风险的可能因果效应。
MR分析显示，OSA与前列腺癌易感性之间存在显著负相关（OR：0.87，95%CI 0.79 - 0.95，p = 0.002），且与胰腺恶性肿瘤易感性存在因果性增加（OR：2.02，95%CI 1.1 - 3.7，p = 0.02）。然而，未发现OSA对其他特定部位癌症有因果效应。敏感性分析未显示显著的异质性或水平多效性，从而验证了原始结果的稳健性。
我们的MR分析为OSA与癌症风险之间的因果关联提供了重要见解，突出了OSA对不同癌症类型的保护作用和潜在危害。
