Pang Qixin, Chang Zhe, Liu Hao, Chen Jianshe, Ma Sicheng, Zhang Chenming, Sun Zixue
Traditional Chinese Medicine (ZHONG JING) School, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
School of Foreign Languages, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
Front Endocrinol (Lausanne). 2025 May 16;16:1541744. doi: 10.3389/fendo.2025.1541744. eCollection 2025.
Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant literature in PubMed and the Web of Science published before May 2024; systematically summarized the progress in the application of Mendelian randomization in male infertility, erectile dysfunction, prostate cancer, and prostatitis; summarized and classified the risk factors affecting men's health, such as the gut microbiota, modifiable risk factors and related diseases; and presented some problems and solutions that were presented in these studies. This information offers valuable insights into the etiology and pathogenesis of male-specific diseases.
尽管在男性医学领域已经开展了大量关于风险因素的孟德尔随机化研究，但仍缺乏对这些研究结果的系统整合。本综述检索了截至2024年5月之前在PubMed和科学网发表的相关文献；系统总结了孟德尔随机化在男性不育症、勃起功能障碍、前列腺癌和前列腺炎应用方面的进展；总结并分类了影响男性健康的风险因素，如肠道微生物群、可改变的风险因素及相关疾病；并提出了这些研究中存在的一些问题及解决方案。这些信息为男性特有疾病的病因和发病机制提供了有价值的见解。
