Stimpel M, Vetter H, Küffer B, Groth H, Greminger P, Vetter W
J Hypertens Suppl. 1985 Apr;3(1):S97-9.
To determine the weight deviation of scored tablets after breaking we took 100 tablets of each of 34 brands of commercially available antihypertensive drugs and broke them into two, using the scored line. We graded the weights of the tablet halves according to their deviation from the expected weight (1 = less than or equal to +/- 5%, 11 = +/- 6-10%, 111 = greater than or equal to +/- 10%). The brands were ranked by the proportion of tablet halves (n = 200) in each category. Only seven brands divided very accurately and 11 brands divided reasonably accurately. Despite the scored line the remainder were either moderately (n = 10) or absolutely (n = 6) unsuitable for breaking, by hand or otherwise. A high proportion of these tablet halves showed weight deviations of 6-10% or more than 10% when compared to the expected weight. These findings show that a great number of antihypertensive drugs do not break evenly despite a scored line. This leads to inaccuracy of dosage.
为了确定刻痕片剂掰断后的重量偏差，我们选取了34种市售抗高血压药物品牌中的每种100片，并利用刻痕线将它们掰成两半。我们根据片剂半片的重量与预期重量的偏差对其进行分级（1级 = 小于或等于±5%，2级 = ±6 - 10%，3级 = 大于或等于±10%）。各品牌按照每个类别中片剂半片（n = 200）的比例进行排名。只有7个品牌分割得非常准确，11个品牌分割得较为准确。尽管有刻痕线，但其余品牌要么中度（n = 10）要么完全（n = 6）不适合手工或其他方式掰断。与预期重量相比，这些片剂半片中很大一部分显示出6 - 10%或超过10%的重量偏差。这些发现表明，尽管有刻痕线，大量抗高血压药物仍不能均匀掰断。这会导致剂量不准确。
