Laboratory of Tumor Virology and Cancer Immunotherapy, Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Laboratory of Tumor Virology and Cancer Immunotherapy, Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Immunol Lett. 2024 Jun;267:106864. doi: 10.1016/j.imlet.2024.106864. Epub 2024 May 3.
Tumor-associated myeloid cells, including macrophages and myeloid-derived suppressor cells, can be highly prevalent in solid tumors and play a significant role in the development of the tumor. Therefore, myeloid cells are being considered potential targets for cancer immunotherapies. In this review, we focused on strategies aimed at targeting tumor-associated macrophages (TAMs). Most strategies were studied preclinically but we also included a limited number of clinical studies based on these strategies. We describe possible underlying mechanisms and discuss future challenges and prospects.
肿瘤相关的髓系细胞，包括巨噬细胞和髓系来源的抑制细胞，在实体瘤中非常普遍，在肿瘤的发展中起着重要作用。因此，髓系细胞被认为是癌症免疫治疗的潜在靶点。在这篇综述中，我们专注于靶向肿瘤相关巨噬细胞（TAMs）的策略。大多数策略都是在临床前研究中进行研究的，但我们也根据这些策略纳入了少量的临床研究。我们描述了可能的潜在机制，并讨论了未来的挑战和前景。
