Department of Thoracic Surgery, Shenyang Chest Hospital & Tenth People's Hospital, Shenyang, Liaoning, China.
Department of Radiotherapy, The People's Hospital of Liaoning Province, Shenyang, Liaoning, China.
Front Immunol. 2024 Sep 30;15:1476565. doi: 10.3389/fimmu.2024.1476565. eCollection 2024.
Tumor-associated macrophages (TAMs) are present in the tumor microenvironment and can polarize into subtypes with different functions and characteristics in response to different stimuli, classifying them into anti-tumorigenic M1-type and pro-tumorigenic M2-type. The M1-type macrophages inhibit tumor growth through the release of pro-inflammatory cytokines, whereas the M2-type macrophages contribute to tumor progression through the promotion of tumor proliferation, angiogenesis and metastasis. Due to the duality of macrophage effects on tumors, TAMs have been a hot topic in tumor research. In this paper, the heterogeneity and plasticity of TAMs, the interactions between TAMs and other immune cells, and the effects of TAMs on tumors are reviewed, and the therapeutic strategies for TAMs are summarized and discussed. These therapeutic strategies encompass methods and approaches to inhibit the recruitment of TAMs, deplete TAMs, and modulate the polarization of TAMs. These studies help to deeply understand the mechanism of TAMs-tumor interaction and provide reference for combination therapy of tumors.
肿瘤相关巨噬细胞（TAMs）存在于肿瘤微环境中，能够在不同刺激下极化为具有不同功能和特征的亚型，分为抗肿瘤的 M1 型和促肿瘤的 M2 型。M1 型巨噬细胞通过释放促炎细胞因子抑制肿瘤生长，而 M2 型巨噬细胞通过促进肿瘤增殖、血管生成和转移促进肿瘤进展。由于巨噬细胞对肿瘤的影响具有双重性，TAMs 一直是肿瘤研究的热点。本文综述了 TAMs 的异质性和可塑性、TAMs 与其他免疫细胞的相互作用以及 TAMs 对肿瘤的影响，并对 TAMs 的治疗策略进行了总结和讨论。这些治疗策略包括抑制 TAMs 募集、耗竭 TAMs 以及调节 TAMs 极化的方法和途径。这些研究有助于深入理解 TAMs-肿瘤相互作用的机制，并为肿瘤的联合治疗提供参考。
