Department of Medical Affairs, Mirvie, Inc., 651 Gateway Boulevard, Suite 1200, South San Francisco, CA 94080, USA.
Department of Research and Development, Mirvie, Inc., 651 Gateway Boulevard, Suite 1200, South San Francisco, CA 94080, USA.
Clin Perinatol. 2024 Jun;51(2):379-389. doi: 10.1016/j.clp.2024.02.008. Epub 2024 Mar 13.
Spontaneous preterm birth (sPTB) is a complex and clinically heterogeneous condition that remains incompletely understood, leading to insufficient interventions to effectively prevent it from occurring. Cell-free ribonucleic acid signatures in the maternal circulation have the potential to identify biologically relevant subtypes of sPTB. These could one day be used to predict and prevent sPTB in asymptomatic individuals, and to aid in prognosis and management for individuals presenting with threatened preterm labor and preterm prelabor rupture of membranes.
自发性早产（sPTB）是一种复杂且临床表现多样的疾病，目前尚未完全被理解，这导致针对其预防的干预措施不足。孕妇循环中无细胞核糖核酸特征具有鉴定 sPTB 生物学相关亚型的潜力。这些特征将来可能用于预测和预防无症状个体的 sPTB，并有助于对有早产先兆和胎膜早破的个体进行预后和管理。
