Université de Montréal, Pavillion Roger-Gaudry, 2900 boul Edouard-Montpetit, H3T 1J4, Montréal, Québec, Canada; Centre de recherche du CHU Sainte-Justine, 3175 ch de la Côte-Sainte-Catherine, H3T 1C5, Montréal, Québec, Canada.
Département de Biologie, Université de Sherbrooke, Voie 9, J1X 2X9, Sherbrooke, Québec, Canada.
Clin Perinatol. 2024 Jun;51(2):497-510. doi: 10.1016/j.clp.2024.02.006. Epub 2024 Mar 26.
This review examines the complexities of preterm birth (PTB), emphasizes the pivotal role of inflammation in the pathogenesis of preterm labor, and assesses current available interventions. Antibiotics, progesterone analogs, mechanical approaches, nonsteroidal anti-inflammatory drugs, and nutritional supplementation demonstrate a limited efficacy. Tocolytic agents, targeting uterine activity and contractility, inadequately prevent PTB by neglecting to act on uteroplacental inflammation. Emerging therapies targeting toll-like receptors, chemokines, and interleukin receptors exhibit promise in mitigating inflammation and preventing PTB.
这篇综述探讨了早产（PTB）的复杂性，强调了炎症在早产发生中的关键作用，并评估了目前可用的干预措施。抗生素、孕激素类似物、机械方法、非甾体抗炎药和营养补充剂的疗效有限。抑制子宫活动和收缩的保胎药物通过忽视对胎盘-子宫炎症的作用，不能充分预防早产。针对 Toll 样受体、趋化因子和白细胞介素受体的新兴治疗方法在减轻炎症和预防早产方面显示出前景。
