Smith T F, Ralph W W, Goodman M, Czelusniak J
Bio-Statistics, Harvard School of Public Health, Northern Michigan University, Marquette 49855.
Mol Biol Evol. 1985 Sep;2(5):390-8. doi: 10.1093/oxfordjournals.molbev.a040358.
A study of codon usage in vertebrate hemoglobins revealed an evolutionary trend toward elevated numbers of CpG codon boundary pairs in mammalian hemoglobin alpha genes. Selection for CpG codon boundaries countering the generally observed CpG suppression is strongly suggested by these data. These observations parallel recently published experimental results that indicate that constitutive expression of the human alpha-globin gene appears to be determined by regulatory information encoded within the structural gene. The possibility is raised that, in the absence of selection, CpG decay can be used to date the evolutionary origin of a mammalian alpha pseudogene from its active alpha gene.
一项关于脊椎动物血红蛋白密码子使用情况的研究表明，哺乳动物血红蛋白α基因中，CpG密码子边界对数量增加呈现出一种进化趋势。这些数据有力地表明，存在针对CpG密码子边界的选择，以对抗普遍观察到的CpG抑制现象。这些观察结果与最近发表的实验结果相似，这些实验结果表明，人类α - 珠蛋白基因的组成型表达似乎由结构基因中编码的调控信息决定。这就提出了一种可能性，即在没有选择的情况下，CpG衰减可用于确定哺乳动物α假基因与其活性α基因在进化上的起源时间。
