University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, California, USA.
J Am Geriatr Soc. 2024 Sep;72(9):2800-2806. doi: 10.1111/jgs.18943. Epub 2024 May 6.
Medication utilization has been increasing in the U.S. year-over-year for several decades. As older adults take more medications, there is a higher risk of them being exposed to drug-drug or drug-disease interactions. The American Geriatrics Society in 2019 updated their Beers Criteria for Potentially Inappropriate Medication (PIM) Use in Older Adults. The objective of this study was to assess the prevalence of utilization of medications included in the 2019 Beers Criteria.
An analysis was conducted using the Medicare Part D Provider Utilization and Payment Data Public Use File for calendar-year 2020. Medications identified in the 2019 Beers Criteria were applied to the analysis. Two categories of medications were assessed: (1) "Avoid" and (2) "Use With Caution."
In 2020, 56 million prescriptions were dispensed to Medicare patients 65 years and older that are recommended to be avoided without exception (4.7% of all prescriptions) totaling $957 million in medication costs. The most utilized medication classes in this category were benzodiazepines (25,949,994 prescriptions), "Z-drugs" (6,204,909 prescriptions), long-acting sulfonylureas (5,306,577 prescriptions), 1st-generation antihistamines (5,049,289 prescriptions), and tricyclic antidepressants (4,190,062 prescriptions). Additionally, 135 million prescriptions were dispensed to Medicare beneficiaries 65 years and older for medications which the Beers Criteria states to use caution (11.3% of all prescriptions) exceeding $2.85 billion in medication costs. The most utilized medications for this category were diuretics (74,599,126 prescriptions), selective serotonin reuptake inhibitors (30,033,121 prescriptions), serotonin and norepinephrine reuptake inhibitors (11,858,968 prescriptions), tramadol (11,450,878 prescriptions), and mirtazapine (5,737,304 prescriptions).
Even with the existence of the AGS Beers Criteria for PIM Use in Older Adults and its continued updated versions, 16% of medications dispensed to Medicare Part D were potentially inappropriate. Future studies are needed to assess if this has led to worsened outcomes among older adults who utilized these PIM.
几十年来,美国的药物使用量逐年增加。随着老年人服用的药物越来越多,他们面临药物-药物或药物-疾病相互作用的风险也越来越高。美国老年医学会在 2019 年更新了他们的老年人潜在不适当药物(PIM)使用的 Beers 标准。本研究的目的是评估 2019 年 Beers 标准中包含的药物使用的流行率。
对 2020 年医保处方药计划(Medicare Part D)提供者使用和支付数据公共使用文件进行了分析。将 2019 年 Beers 标准中确定的药物应用于分析。评估了两类药物:(1)“避免”和(2)“谨慎使用”。
2020 年,有 5600 万份推荐无例外避免使用的处方(占所有处方的 4.7%)分配给了 65 岁及以上的 Medicare 患者,这些处方的药物费用总计 9.57 亿美元。在这一类别中使用最多的药物类别是苯二氮䓬类(2594994 份处方)、“Z 类药物”(6204909 份处方)、长效磺酰脲类(5306577 份处方)、第一代抗组胺药(5049289 份处方)和三环类抗抑郁药(4190062 份处方)。此外,有 1.35 亿份处方分配给了 65 岁及以上的 Medicare 受益人,这些处方的药物是 Beers 标准中建议谨慎使用的药物(占所有处方的 11.3%),药物费用超过 28.5 亿美元。对于这一类药物,使用最多的是利尿剂(74599126 份处方)、选择性 5-羟色胺再摄取抑制剂(30033121 份处方)、5-羟色胺和去甲肾上腺素再摄取抑制剂(11858968 份处方)、曲马多(11450878 份处方)和米氮平(5737304 份处方)。
即使有美国老年医学会老年人潜在不适当药物使用的 Beers 标准及其不断更新的版本,仍有 16%分配给 Medicare Part D 的药物可能是不适当的。需要进一步研究以评估这是否导致使用这些 PIM 的老年人的结局恶化。