Department of Radiology and Nuclear Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
PLoS One. 2024 May 6;19(5):e0302896. doi: 10.1371/journal.pone.0302896. eCollection 2024.
To investigate changes in chest CT between 3 and 12 months and associations with disease severity in patients hospitalized for COVID-19 during the first wave in 2020.
Longitudinal cohort study of patients hospitalized for COVID-19 in 2020. Chest CT was performed 3 and 12 months after admission. CT images were evaluated using a CT severity score (CSS) (0-12 scale) and recoded to an abbreviated version (0-3 scale). We analyzed determinants of the abbreviated CSS with multivariable mixed effects ordinal regression.
242 patients completed CT at 3 months, and 124 (mean age 62.3±13.3, 78 men) also at 12 months. Between 3 and 12 months (n = 124) CSS (0-12 scale) for ground-glass opacities (GGO) decreased from median 3 (25th-75th percentile: 0-12) at 3 months to 0.5 (0-12) at 12 months (p<0.001), but increased for parenchymal bands (p<0.001). In multivariable analysis of GGO, the odds ratio for more severe abbreviated CSS (0-3 scale) at 12 months was 0.11 (95%CI 0.11 0.05 to 0.21, p<0.001) compared to 3 months, for WHO severity category 5-7 (high-flow oxygen/non-invasive ventilation/ventilator) versus 3 (non-oxygen use) 37.16 (1.18 to 43.47, p = 0.032), and for age ≥60 compared to <60 years 4.8 (1.33 to 17.6, p = 0.016). Mosaicism was reduced at 12 compared to 3 months, OR 0.33 (95%CI 0.16 to 0.66, p = 0.002).
GGO and mosaicism decreased, while parenchymal bands increased from 3 to 12 months. Persistent GGO were associated with initial COVID-19 severity and age ≥60 years.
研究 2020 年 COVID-19 第一波期间住院患者在 3 至 12 个月期间的胸部 CT 变化，并探讨其与疾病严重程度的关系。
对 2020 年 COVID-19 住院患者进行纵向队列研究。入院后 3 个月和 12 个月进行胸部 CT 检查。使用 CT 严重程度评分（CSS）（0-12 分）评估 CT 图像，并将其重新编码为缩写版本（0-3 分）。我们使用多变量混合效应有序回归分析缩写 CSS 的决定因素。
242 例患者在 3 个月时完成 CT 检查，124 例（平均年龄 62.3±13.3，78 例男性）在 12 个月时也完成 CT 检查。在 3 至 12 个月（n=124）期间，磨玻璃影（GGO）的 CSS（0-12 分）中位数从 3 个月时的 3（25 至 75 分位：0-12）降至 12 个月时的 0.5（0-12）（p<0.001），但实质带的 CSS 增加（p<0.001）。多变量分析 GGO 时，与 3 个月相比，12 个月时更严重的缩写 CSS（0-3 分）的比值比为 0.11（95%CI 0.11 0.05 至 0.21，p<0.001），与 WHO 严重程度类别 5-7（高流量氧/无创通气/呼吸机）与 3（非吸氧）相比，37.16（1.18 至 43.47，p=0.032），与年龄≥60 岁相比，年龄<60 岁的比值为 4.8（1.33 至 17.6，p=0.016）。与 3 个月相比，12 个月时镶嵌征减少，OR 0.33（95%CI 0.16 至 0.66，p=0.002）。
从 3 个月到 12 个月，GGO 和镶嵌征减少，而实质带增加。持续的 GGO 与初始 COVID-19 严重程度和年龄≥60 岁有关。
