BachMai Stroke Center, BachMai Hospital, Hanoi, Vietnam.
VNU University of Medicine and Pharmacy, Hanoi, Vietnam.
PLoS One. 2024 May 6;19(5):e0302822. doi: 10.1371/journal.pone.0302822. eCollection 2024.
Early neurological deterioration (END) is progressive neurological deterioration with an increase in NIHSS score of 2 points or more in the first 72 hours from the onset of acute ischemic stroke. END increases the risk of poor clinical outcomes at day 90 of ischemic stroke. We will study the frequency, predictors, and outcomes of patients with END in a case-control study at a comprehensive stroke centre in Vietnam. of the design is a descriptive observational study, longitudinal follow-up of patients with minor stroke hospitalized at the Stroke Center of Bach Mai Hospital from December 1, 2023, to December 1, 2024. Minor stroke patients characterized by NIHSS score ≤ 5 hospitalized within 24 hours of symptom onset will be recruited. The estimated END rate is about 30%, relative accuracy ε = 0.11, 95% reliability, expected 5% of patients lost data or follow-up, and an estimated sample size of 779 patients. This study will help determine the END rate in patients with minor stroke and related factors, thereby building a prognostic model for END. Our study determined the END rate in patients with minor stroke in Vietnam and also proposed risk factors for minor stroke management and treatment.
早期神经功能恶化（END）是指急性缺血性脑卒中发病后 72 小时内 NIHSS 评分增加 2 分或以上的进行性神经功能恶化。END 增加了缺血性脑卒中第 90 天不良临床结局的风险。我们将在越南的一家综合卒中中心进行一项病例对照研究，研究 END 患者的频率、预测因素和结局。该研究设计为描述性观察性研究，对 2023 年 12 月 1 日至 2024 年 12 月 1 日期间在 Bach Mai 医院卒中中心住院的轻度卒中患者进行纵向随访。轻度卒中患者的特点是 NIHSS 评分≤5，症状发作后 24 小时内住院。预计 END 发生率约为 30%，相对精度 ε = 0.11，95%可靠性，预计 5%的患者失访或随访，预计样本量为 779 例。这项研究将有助于确定轻度卒中患者的 END 发生率及其相关因素，从而建立 END 的预后模型。我们的研究确定了越南轻度卒中患者的 END 发生率，并提出了轻度卒中管理和治疗的危险因素。
