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由恶性肿瘤引发的他汀类药物诱导的免疫介导性坏死性肌病经免疫抑制治疗后成功缓解。

Statin-induced, immune-mediated necrotising myopathy triggered by malignancy successfully treated with immunosuppression.

机构信息

Portsmouth University Hospital, UK.

出版信息

Clin Med (Lond). 2024 May;24(3):100217. doi: 10.1016/j.clinme.2024.100217. Epub 2024 May 6.

DOI:10.1016/j.clinme.2024.100217
PMID:38710328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11108855/
Abstract

Statin-induced immune-mediated necrotising myopathy (IMNM) is an inflammatory myopathy that can present as proximal muscle weakness and, in some cases, as dysphagia and respiratory distress. In this report, we present a case of statin-induced IMNM in a 78-year-old male. The patient had significantly high levels of creatinine kinase and myoglobinuria and experienced gradual weakness in the proximal muscles for 1 month after initiating a 20 mg dose of Atorvastatin 10 months before admission. Rapid clinical improvement was observed with the use of high-dose glucocorticoids in conjunction with methotrexate.

摘要

他汀类药物引起的免疫介导的坏死性肌病（IMNM）是一种炎症性肌病，可表现为近端肌无力，在某些情况下还可表现为吞咽困难和呼吸窘迫。在本报告中，我们介绍了一例 78 岁男性的他汀类药物引起的 IMNM。患者在入院前 10 个月开始服用阿托伐他汀 20mg 时，肌酸激酶和肌红蛋白尿显著升高，且出现逐渐的近端肌无力，持续 1 个月。使用大剂量糖皮质激素联合甲氨蝶呤治疗后，患者的病情迅速改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c3/11108855/fbf3f636bf46/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c3/11108855/6da1a59e9085/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c3/11108855/a145263148a4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c3/11108855/fbf3f636bf46/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c3/11108855/6da1a59e9085/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c3/11108855/a145263148a4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13c3/11108855/fbf3f636bf46/gr3.jpg

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Rheumatol Int. 2025 Apr 18;45(5):109. doi: 10.1007/s00296-025-05860-0.
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Doing simple things well can achieve significant benefits.把简单的事情做好能带来显著的益处。
Clin Med (Lond). 2024 May;24(3):100219. doi: 10.1016/j.clinme.2024.100219.