心脏中 IGF-1 信号的新见解。
New Insights into IGF-1 Signaling in the Heart.
机构信息
Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States.
出版信息
Physiology (Bethesda). 2024 Sep 1;39(5):0. doi: 10.1152/physiol.00003.2024. Epub 2024 May 7.
Insulin-like growth factor-1 (IGF-1) signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart diseases and contribute to the progression of heart failure. This review highlights the critical role of IGF-1 and its cognate receptor in cardiac hypertrophy, aging, and remodeling.
胰岛素样生长因子-1（IGF-1）信号在细胞生长、代谢和衰老过程中具有多种生理作用。心肌肥厚、细胞死亡、衰老、纤维化和电重构是各种心脏疾病的特征，并促进心力衰竭的进展。本文重点介绍了 IGF-1 及其同源受体在心脏肥大、衰老和重构中的关键作用。
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