Department of Immunology, Binzhou Medical University, Yantai, China.
Department of Immunology, Qiqihar Medical University, Qiqihar, China.
Med Oncol. 2024 May 7;41(6):141. doi: 10.1007/s12032-024-02373-x.
IGFBP-3 is aberrantly expressed in many tumor types, and its serum and tumor tissue levels provide auxiliary information for assessing the degree of tumor malignancy and patient prognosis, making it a potential therapeutic target for human malignancies and conferring it remarkable clinical value for determining patient prognosis. In this review, we provide a comprehensive overview of the aberrant expression, diverse biological effects, and clinical implications of IGFBP-3 in tumors and its role as a potential prognostic marker and therapeutic target for tumors. In addition, we summarize the signaling pathways through which IGFBP-3 exerts its effects. IGFBP-3 comprises an N-terminal, an intermediate region, and a C-terminal structural domain, each exerting different biological effects in several tumor cell types in an IGF-dependent/non-independent manner. IGFBP-3 shares an intricate relationship with the tumor microenvironment, thereby affecting tumor growth. Overall, IGFBP-3 is an essential regulatory factor that mediates tumor occurrence and progression. Gaining deeper insights into the fundamental characteristics of IGFBP-3 and its role in various tumor types will provide new perspectives and allow for the development of novel strategies for cancer diagnosis, treatment, and prognostic evaluation.
IGFBP-3 在许多肿瘤类型中异常表达，其血清和肿瘤组织水平为评估肿瘤恶性程度和患者预后提供辅助信息，使其成为人类恶性肿瘤的潜在治疗靶点，并为确定患者预后提供显著的临床价值。在这篇综述中，我们全面概述了 IGFBP-3 在肿瘤中的异常表达、多种生物学效应及其作为肿瘤潜在预后标志物和治疗靶点的作用。此外，我们总结了 IGFBP-3 发挥作用的信号通路。IGFBP-3 包含 N 端、中间区域和 C 端结构域，每个结构域以 IGF 依赖/非依赖的方式在几种肿瘤细胞类型中发挥不同的生物学效应。IGFBP-3 与肿瘤微环境密切相关，从而影响肿瘤的生长。总的来说，IGFBP-3 是一种重要的调节因子，介导肿瘤的发生和发展。深入了解 IGFBP-3 的基本特征及其在各种肿瘤类型中的作用将为癌症诊断、治疗和预后评估提供新的视角，并为开发新的策略提供可能。
