Storch T G, Arnstein P, Manohar V, Leiserson W M, Chused T M
J Natl Cancer Inst. 1985 Jan;74(1):137-43.
NFS/N mice inoculated with Moloney murine leukemia virus (M-MuLV) developed T-cell lymphoma after a 10-week latent period. Expression of lymphoid differentiation antigens, appearance of M-MuLV-encoded cell surface antigens, and rates of cellular proliferation were measured in splenic and bone marrow subpopulations during this latent period. At 2 weeks of age, Thy-1-and surface immunoglobulin-negative null cells of spleen and bone marrow expressed M-MuLV antigens whereas T- and B-lymphocytes did not. During the 3d and 4th weeks, the number of splenic null cells increased to six times the number found in uninfected controls. These null cells included the precursors of lymphocytes and hematopoietic cells. For the remainder of the latent period, the percentage of null cells undergoing proliferation was three times greater in the infected mice, while the total number of null cells remained constant. This proliferation was not accompanied by terminal differentiation or emigration of mature cell types from the spleen. Proliferation was substantially delayed in CBA mice, which are resistant to lymphoma induction.
接种莫洛尼鼠白血病病毒（M-MuLV）的NFS/N小鼠在10周潜伏期后发生了T细胞淋巴瘤。在此潜伏期内，对脾脏和骨髓亚群中的淋巴样分化抗原表达、M-MuLV编码的细胞表面抗原出现情况以及细胞增殖速率进行了测量。在2周龄时，脾脏和骨髓中Thy-1及表面免疫球蛋白阴性的裸细胞表达M-MuLV抗原，而T淋巴细胞和B淋巴细胞则不表达。在第3周和第4周，脾脏裸细胞数量增加到未感染对照的6倍。这些裸细胞包括淋巴细胞和造血细胞的前体。在潜伏期的其余时间里，感染小鼠中发生增殖的裸细胞百分比是未感染小鼠的3倍，而裸细胞总数保持不变。这种增殖并未伴随着终末分化或成熟细胞类型从脾脏中迁出。CBA小鼠对淋巴瘤诱导具有抗性，其增殖明显延迟。
