甘油三酯-葡萄糖指数与肥胖患者亚临床左心室收缩功能障碍的关系。

Association between the triglyceride-glucose index and subclinical left ventricular systolic dysfunction in obese patients.

机构信息

Department of Echocardiography, The Affiliated Changzhou Second People's Hospital with Nanjing Medical University, 213003, Changzhou, China.

Department of Weight Loss Metabolic Surgery, The Affiliated Changzhou Second People's Hospital with Nanjing Medical University, 213003, Changzhou, China.

出版信息

Cardiovasc Diabetol. 2024 May 7;23(1):161. doi: 10.1186/s12933-024-02253-8.

DOI:10.1186/s12933-024-02253-8

PMID:38715070

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11077869/

Abstract

BACKGROUND

The association between the triglyceride-glucose (TyG) index and subclinical left ventricular (LV) systolic dysfunction in obese patients remains unclear. This study aimed to investigate the relationship between the TyG index and LV global longitudinal strain (GLS) in obese patients.

METHODS

A total of 1028 obese patients from January 2019 to January 2024 were included in the present study. Clinical parameters and biochemical and echocardiographic data were obtained from the participants. LV GLS was obtained from the GE EchoPAC workstation for evaluating subclinical LV function. The TyG index was calculated as Ln (fasting TG [mg/dL] × fasting glucose [mg/dL]/2). LV GLS was compared between obese patients with a high TyG index and those with a low TyG index.

RESULTS

Obese patients with a high TyG index had greater incidences of hypertension, diabetes mellitus and hyperlipidaemia. The LV GLS was significantly lower in the high TyG index group than in the low TyG index group (P = 0.01). After adjusting for sex, age, body mass index, heart rate, hypertension, diabetes mellitus, dyslipidaemia, blood urea nitrogen, serum creatinine, LV mass and LV hypertrophy, the TyG index remained an independent risk indicator related to an LV GLS < 20% (OR: 1.520, 95% CI: 1.040 to 2.221; P = 0.031).

CONCLUSIONS

We concluded that an increase in the TyG index is independently associated with subclinical LV systolic dysfunction in obese patients.

摘要

背景

甘油三酯-葡萄糖（TyG）指数与肥胖患者亚临床左心室（LV）收缩功能障碍之间的关系尚不清楚。本研究旨在探讨 TyG 指数与肥胖患者 LV 整体纵向应变（GLS）之间的关系。

方法

本研究纳入了 2019 年 1 月至 2024 年 1 月期间的 1028 名肥胖患者。从参与者中获取临床参数和生化及超声心动图数据。使用 GE EchoPAC 工作站获取 LV GLS，用于评估亚临床 LV 功能。TyG 指数的计算方法为 Ln（空腹 TG[mg/dL]×空腹血糖[mg/dL]/2）。比较 TyG 指数高和低的肥胖患者的 LV GLS。

结果

TyG 指数高的肥胖患者高血压、糖尿病和高脂血症的发生率更高。高 TyG 指数组的 LV GLS 明显低于低 TyG 指数组（P=0.01）。在调整性别、年龄、体重指数、心率、高血压、糖尿病、血脂异常、尿素氮、血清肌酐、LV 质量和 LV 肥厚后，TyG 指数仍然是与 LV GLS<20%相关的独立危险因素（OR：1.520，95%CI：1.040 至 2.221；P=0.031）。