Veterinary Clinic for Reproductive Medicine and Neonatology, Justus Liebig University, Giessen, Germany.
Institute of Veterinary Anatomy, Vetsuisse-Faculty, University of Zurich, Zurich, Switzerland.
BMC Vet Res. 2024 May 7;20(1):181. doi: 10.1186/s12917-024-04035-6.
The risk of developing tumorous diseases in the genital tract also increases with age in animals. One of the classified tumor types is genital leiomyoma. Presently, our understanding of the pathogenesis of this tumor in goats is, however, limited. This accounts also for the information regarding the presence of steroid hormone receptors and, thus, possible responsiveness to circulating steroids.
This study describes the case of a vaginal tumor in a seven-year-old Anglo-Nubian goat. The goat was presented due to blood mixed vaginal discharge. Per vaginal examination a singular pedunculated mass in the dorsum of the vagina measuring approximately 3 cm x 4 cm x 4 cm was revealed. After administering epidural anesthesia, the mass was removed electrothermally. There were no postoperative complications. The histopathological examination identified the mass as a leiomyoma. The immunohistochemical examination revealed the presence of the nuclear progesterone receptor (PGR) in the tumor tissue. One year after the surgery, during the follow-up examination, the goat was in good overall health, and the owners had not observed any recurrence of vaginal discharge.
When observing vaginal discharge in goats, it is important to consider the possibility of genital tract tumors. These tumors may express sex steroid receptors. In the future, it is worth considering the investigation of potential approaches for preventing tumorigenesis or treating the tumor, such as castration or the administration of antiprogestogens.
动物生殖道肿瘤的风险也会随着年龄的增长而增加。其中一种分类的肿瘤类型是生殖道平滑肌瘤。然而，目前我们对山羊这种肿瘤的发病机制了解有限。这也说明了甾体激素受体的存在及其对循环甾体激素的可能反应。
本研究描述了一例七岁安哥拉-努比亚山羊阴道肿瘤的病例。这只山羊因阴道混合出血而就诊。经阴道检查，在阴道背部发现一个单一的有蒂肿块，大小约为 3 cm x 4 cm x 4 cm。在给予硬膜外麻醉后，用电热法切除了肿块。术后无并发症。组织病理学检查将肿块确定为平滑肌瘤。免疫组织化学检查显示肿瘤组织中存在核孕激素受体（PGR）。术后一年，在随访检查中，这只山羊整体健康状况良好，主人没有观察到任何阴道分泌物复发的情况。
在观察山羊阴道分泌物时，重要的是要考虑生殖道肿瘤的可能性。这些肿瘤可能表达性甾体激素受体。将来，值得考虑探索预防肿瘤发生或治疗肿瘤的潜在方法，如去势或使用抗孕激素。
