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基于[具体物质]的饲料补充剂通过下调Bax/半胱天冬酶3信号通路来预防肾缺血/再灌注损伤。

-based feed supplement protects against renal ischaemia/reperfusion injury via downregulation of Bax/caspase 3 signaling.

作者信息

Afolabi Oladele A, Akhigbe Tunmise M, Hammed Sodiq O, Hamed Moses A, Ekundina Victor O, Ajike Richard A, Alabi Babatunde A, Akhigbe Roland E

机构信息

Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria.

Department of Agronomy, Osun State University, Osogbo, Nigeria.

出版信息

Front Nutr. 2024 Apr 23;11:1396864. doi: 10.3389/fnut.2024.1396864. eCollection 2024.

DOI:10.3389/fnut.2024.1396864
PMID:38716072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11074472/
Abstract

INTRODUCTION

Ischaemia/reperfusion (I/R) may lead to acute kidney injury via the induction of oxidative stress. On the other hand, Moringa oleifera has been reported to exert antioxidant activities. This study was designed to assess whether or not Moringa oleifera-based feed supplement could prevent I/R-induced renal injury.

MATERIALS AND METHODS

Renal I/R was induced by occluding the right renal artery for 30  min followed by a 2-h reperfusion.

RESULTS

Renal I/R led to increased absolute renal weight and renal organo-somatic weight index. Renal I/R also caused distortion of renal histoarchitecture and impaired renal function evidenced by elevated serum creatinine and blood urea nitrogen. In addition, renal I/R significantly elevated renal levels of hydrogen peroxide, MDA, and advanced oxidation protein products, but suppressed the levels of reduced glutathione, protein thiol, and non-protein thiol, and the activities of superoxide dismutase and glutathione peroxidase. In addition, renal I/R up-regulated myeloperoxidase activity and the renal levels of NO, TNF-α, and IL-6. Renal I/R also up-regulated Bax and caspase 3 expression in the kidney. Furthermore, I/R-driven structural and biochemical alterations were markedly inhibited by Moringa oleifera-based feed supplement.

DISCUSSION

These results suggest that Moringa oleifera-based feed supplement may preserve the gross and histoarchitectural integrity of the kidney as well as renal function via downregulation of Bax/caspase 3 signaling by targeting oxidative stress, inflammation and apoptosis in the kidney of I/R rat.

摘要

引言

缺血/再灌注（I/R）可通过诱导氧化应激导致急性肾损伤。另一方面，据报道辣木具有抗氧化活性。本研究旨在评估基于辣木的饲料补充剂是否能预防I/R诱导的肾损伤。

材料与方法

通过阻断右肾动脉30分钟，随后再灌注2小时来诱导肾I/R。

结果

肾I/R导致肾绝对重量和肾器官-体质量指数增加。肾I/R还导致肾组织结构扭曲和肾功能受损，表现为血清肌酐和血尿素氮升高。此外，肾I/R显著提高了肾过氧化氢、丙二醛和晚期氧化蛋白产物的水平，但降低了还原型谷胱甘肽、蛋白巯基和非蛋白巯基的水平以及超氧化物歧化酶和谷胱甘肽过氧化物酶的活性。此外，肾I/R上调了髓过氧化物酶活性以及肾一氧化氮、肿瘤坏死因子-α和白细胞介素-6的水平。肾I/R还上调了肾组织中Bax和半胱天冬酶3的表达。此外，基于辣木的饲料补充剂显著抑制了I/R引起的结构和生化改变。

讨论

这些结果表明，基于辣木的饲料补充剂可能通过下调Bax/半胱天冬酶3信号通路，靶向I/R大鼠肾脏中的氧化应激、炎症和细胞凋亡，从而维持肾脏的大体和组织结构完整性以及肾功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/d6e50e67fc6f/fnut-11-1396864-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/438a5526ae47/fnut-11-1396864-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/c3c4365286a6/fnut-11-1396864-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/0f24e98b1772/fnut-11-1396864-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/06c722db6dcb/fnut-11-1396864-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/1ce4efff58ec/fnut-11-1396864-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/ca1e12712ca7/fnut-11-1396864-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/d6e50e67fc6f/fnut-11-1396864-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/438a5526ae47/fnut-11-1396864-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/c3c4365286a6/fnut-11-1396864-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/0f24e98b1772/fnut-11-1396864-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/06c722db6dcb/fnut-11-1396864-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/1ce4efff58ec/fnut-11-1396864-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/ca1e12712ca7/fnut-11-1396864-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d661/11074472/d6e50e67fc6f/fnut-11-1396864-g007.jpg

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