Ge Jinfeng, Ma Chao, Qi Yulin, Wang Xiaowei, Wang Wei, Hu Miao, Hu Qiaozhuan, Yi Yuan-Bi, Shi Dejun, Yue Fu-Jun, Li Si-Liang, Volmer Dietrich A
Institute of Surface-Earth System Science School of Earth System Science Tianjin University Tianjin China.
Tianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai Rim Tianjin University Tianjin China.
Anal Sci Adv. 2020 Nov 24;2(5-6):272-278. doi: 10.1002/ansa.202000123. eCollection 2021 Jun.
Mass resolving power is one of the key features of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), which enables the molecular characterization of complex mixtures. Quadrupole (2ω) detection provides a significant step forward in FT-ICR MS performance, as it doubles the resolving power for a given signal acquisition time. Whether this 2ω detection technique truly substitutes for a higher magnetic field remains unknown however. In this study, a residue oil sample was characterized using both a 2ω 7 Tesla FT-ICR and a 15 Tesla FT-ICR instrument, and analytical figures of merit were systematically compared. It was shown that 2ω 7T FT-ICR MS provided comparable performance in the deep profiling of the complex oil sample, with better signal intensities and reproducibilities for absorption-mode processing. The 15T FT-ICR MS gave more precise measurements with better estimates of the sample's elemental compositions. To the best of our knowledge, this is the first published study, which thoroughly compared the performance of 2ω detection on a low magnetic field instrument with that of a high magnetic field FT-ICR-MS.
质量分辨能力是傅里叶变换离子回旋共振质谱（FT-ICR MS）的关键特性之一，它能够对复杂混合物进行分子表征。四极杆（2ω）检测在FT-ICR MS性能方面向前迈出了重要一步，因为在给定的信号采集时间内，它能使分辨能力提高一倍。然而，这种2ω检测技术是否真的能替代更高的磁场尚不清楚。在本研究中，使用一台2ω 7特斯拉FT-ICR和一台15特斯拉FT-ICR仪器对一个渣油样品进行了表征，并系统地比较了各项分析性能指标。结果表明，2ω 7T FT-ICR MS在复杂油样的深度剖析中提供了相当的性能，在吸收模式处理下具有更好的信号强度和重现性。15T FT-ICR MS给出了更精确的测量结果，对样品元素组成的估计也更好。据我们所知，这是首次发表的全面比较低磁场仪器上2ω检测与高磁场FT-ICR-MS性能的研究。
