Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati, India.
Chirality. 2024 May;36(5):e23670. doi: 10.1002/chir.23670.
Metal clusters have drawn considerable research attention over the years due to their fascinating optical properties. Owing to their appealing photophysical characteristics, these materials have drawn attention as potential candidates for various application in diverse fields, including disease detection, biosensing, chemical sensing, and the fabrication of light-harvesting materials. Presently, there is an increasing research focus on the use of clusters in biomedical research, both as biodetection platform and as bioimaging agents. Of special interest are chiral clusters, which can selectively interact with chiral biomolecules owing to their optical activity. Herein, we showcase the use of a pair of chiroptically active copper clusters for the enantioselective detection of lysine, an amino acid of vast biological relevance. Two techniques are concurrently employed for the detection of lysine at varying concentrations. Circular dichroism serves as a potent tool for detecting lysine at low concentrations, whereas luminescence is effectively employed as a detection method for high analyte concentrations. The combined electronic impact of clusters and lysine resulted in the emergence of an enhanced enantioselective Cotton effect at specific wavelength.
多年来，金属团簇因其迷人的光学性质引起了相当多的研究关注。由于其吸引人的光物理特性，这些材料作为各种应用的潜在候选材料引起了人们的关注，包括疾病检测、生物传感、化学传感和光收集材料的制造。目前，人们越来越关注将团簇用于生物医学研究，作为生物检测平台和生物成像剂。特别有趣的是手性团簇，由于其光学活性，它们可以选择性地与手性生物分子相互作用。在此，我们展示了一对手性活性铜团簇在赖氨酸对映选择性检测中的应用，赖氨酸是一种具有广泛生物学相关性的氨基酸。同时采用两种技术在不同浓度下检测赖氨酸。圆二色性是检测低浓度赖氨酸的有力工具，而荧光则有效地用作高分析物浓度的检测方法。团簇和赖氨酸的共同电子影响导致在特定波长下出现增强的对映选择性 Cotton 效应。
